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Last updated: September 8, 2025View editorial policy

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Differential Diagnosis for a Patient with Swollen Mouth and Gums

Single Most Likely Diagnosis

  • Gingivitis: This is the most common cause of swollen gums and is often due to poor oral hygiene, leading to the accumulation of plaque and bacteria on the teeth.

Other Likely Diagnoses

  • Periodontitis: An infection of the gums that can cause swelling, redness, and bleeding. It's a progression of gingivitis and can lead to more severe complications if not treated.
  • Dental Abscess: A localized infection that can cause swelling and pain in the mouth and gums. It often requires urgent dental attention.
  • Allergic Reaction: An allergic reaction to food, medication, or dental materials can cause swelling in the mouth and gums.
  • Oral Infection: Infections such as herpetic stomatitis or oral thrush can cause swelling and discomfort in the mouth and gums.

Do Not Miss Diagnoses

  • Angioedema: A severe, potentially life-threatening allergic reaction that can cause rapid swelling of the mouth, gums, and airways. Prompt recognition and treatment are crucial.
  • Ludwig's Angina: A severe infection of the tissues in the neck that can cause swelling, pain, and difficulty swallowing. It's a medical emergency that requires immediate attention.
  • Oral Cancer: Although less common, oral cancer can present with swelling, ulcers, or red and white patches in the mouth. Early detection is key to effective treatment.

Rare Diagnoses

  • Ehlers-Danlos Syndrome: A genetic disorder that can affect the connective tissue in the body, including the gums, leading to swelling and other oral manifestations.
  • Scurvy: A disease caused by vitamin C deficiency that can lead to swollen gums, among other symptoms.
  • Granulomatosis with Polyangiitis (GPA): A rare autoimmune disorder that can cause inflammation and swelling in various parts of the body, including the mouth and gums.
  • Melkersson-Rosenthal Syndrome: A rare neurological disorder that can cause swelling of the face, lips, and gums, along with other symptoms like facial paralysis and the development of folds and furrows in the tongue.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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