Bromfed Dosage for Adults
The recommended dosage of Bromfed for adults is 10 mL (2 teaspoonfuls) every 4 hours, not to exceed 6 doses in a 24-hour period. 1
Dosing Information
Bromfed contains brompheniramine maleate, which is an antihistamine used for treating symptoms associated with allergies and upper respiratory conditions. The FDA-approved dosing recommendations are:
- Adults and children 12 years and older: 10 mL (2 teaspoonfuls) every 4 hours
- Children 6 to under 12 years: 5 mL (1 teaspoonful) every 4 hours
- Children 2 to under 6 years: 2.5 mL (½ teaspoonful) every 4 hours
- Infants 6 months to under 2 years: Dosage to be established by a physician
Important: Do not exceed 6 doses during a 24-hour period 1
Pharmacokinetic Considerations
Brompheniramine has a relatively long half-life of approximately 24.9 ± 9.3 hours and a large volume of distribution (11.7 ± 3.1 L/kg) 2. This contributes to its prolonged antihistaminic effects, with studies showing:
- Peak serum concentration occurs at approximately 3.1 ± 1.1 hours after administration
- Significant suppression of histamine-induced wheal response for 3-9 hours
- Significant suppression of flare response for 3-48 hours
- Significant suppression of pruritus for 9-24 hours 2
Efficacy and Side Effects
Clinical studies have demonstrated that brompheniramine is effective in reducing symptoms such as:
- Rhinorrhea (runny nose)
- Sneezing
- Cough associated with rhinovirus colds 3
Common Side Effects
Be aware that brompheniramine may cause:
- Somnolence (drowsiness)
- Confusion
- Impaired visuo-motor coordination 4
Administration Tips
- The medication can be taken with or without food
- For optimal symptom control, maintain regular dosing intervals
- If a dose is missed, take it as soon as remembered, but do not double up doses
- Consider timing doses to avoid periods when alertness is required, as drowsiness is a common side effect
Cautions and Contraindications
Exercise caution when prescribing Bromfed to patients with:
- Glaucoma
- Urinary retention
- Cardiovascular conditions
- Respiratory conditions like asthma
- Patients operating machinery or driving vehicles
Monitoring
Monitor patients for:
- Symptom relief
- Side effects, particularly sedation
- Drug interactions, especially with other CNS depressants
The regular dosing schedule of every 4 hours provides consistent symptom relief while maintaining therapeutic blood levels throughout the day.