Vulvovaginal Candidiasis: This is a common condition caused by a yeast infection, often presenting with vaginal itching, redness, and discharge. Flu-like symptoms can sometimes accompany the infection, especially if it's severe or the patient has a compromised immune system.

Bacterial Vaginosis (BV): BV can cause vaginal itching, burning, and an abnormal discharge. While it doesn't typically cause flu-like symptoms directly, the discomfort and infection could potentially lead to systemic symptoms in some cases.
Trichomoniasis: A sexually transmitted infection that can cause vaginal itching, burning, redness, and a foul-smelling discharge. Systemic symptoms like fever can occur, especially in more severe cases.
Urinary Tract Infection (UTI): While primarily causing symptoms like dysuria and frequent urination, a UTI can sometimes lead to vaginal itching and, in severe cases, systemic symptoms resembling the flu.

Pelvic Inflammatory Disease (PID): A serious condition that requires prompt treatment, PID can cause lower abdominal pain, fever, and vaginal discharge. It's crucial to consider PID in the differential diagnosis due to its potential for severe complications, including infertility and chronic pelvic pain.
Toxic Shock Syndrome (TSS): Although rare, TSS is a life-threatening condition that can arise from bacterial infections, including those causing vaginal symptoms. It presents with high fever, vomiting, diarrhea, abdominal pain, and sometimes a rash. Early recognition is critical.

Lichen Sclerosus: A chronic skin condition that can cause itching, pain, and scarring in the genital area. While it doesn't typically cause flu-like symptoms, it's a consideration in cases of persistent or severe vaginal itching.
Desquamative Inflammatory Vaginitis (DIV): A rare condition characterized by vaginal inflammation and a significant amount of vaginal discharge. It can cause itching and burning but is less likely to be associated with flu-like symptoms.