Augmentin (Amoxicillin/Clavulanate) Dosing with GFR of 57 mL/min/1.73m²
Yes, you can safely take Augmentin with a GFR of 57 mL/min/1.73m² without dose adjustment, as this level of renal function is considered mild impairment and does not require modification of the standard dosing regimen. 1
Understanding Renal Function and Medication Dosing
A GFR of 57 mL/min/1.73m² falls into the category of mild-to-moderate renal impairment (GFR category G3a: 45-59 mL/min/1.73m²). According to the KDOQI guidelines, this level of kidney function requires consideration for medication dosing, but many medications can still be used at standard doses.
Augmentin-Specific Considerations:
- Amoxicillin and clavulanic acid (the components of Augmentin) are primarily excreted by the kidneys
- Dose adjustment is generally not required until GFR falls below 30 mL/min/1.73m²
- With your GFR of 57, standard dosing is appropriate
Dosing Recommendations Based on Renal Function
| GFR Range (mL/min/1.73m²) | Augmentin Dosing Recommendation |
|---|---|
| >60 (Normal to mild) | Standard dosing |
| 30-60 (Moderate) | Standard dosing |
| 10-30 (Severe) | Reduced dose or extended interval |
| <10 (Kidney failure) | Significantly reduced dose |
Monitoring Recommendations
While taking Augmentin with your current renal function:
- Monitor for signs of efficacy (improvement in infection symptoms)
- Watch for potential side effects (gastrointestinal disturbances, rash)
- Be aware of potential drug interactions
- Consider periodic assessment of kidney function if on extended therapy
Important Precautions
Temporary suspension of medication may be warranted during:
- Acute illness with dehydration
- Before procedures with IV contrast
- Episodes of acute kidney injury
Avoid concurrent use of other potentially nephrotoxic medications when possible, particularly:
- NSAIDs (ibuprofen, naproxen)
- Certain diuretics
- Other medications that may affect kidney function
When to Seek Medical Attention
Contact your healthcare provider if you experience:
- Worsening kidney function
- Signs of allergic reaction
- Severe diarrhea
- No improvement in infection symptoms after 2-3 days
Remember that while your current GFR of 57 allows for standard Augmentin dosing, any significant decline in kidney function may necessitate dose adjustment in the future.