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Last updated: September 9, 2025View editorial policy

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Differential Diagnosis for Chest Pain in Pediatric Patients

Single Most Likely Diagnosis

  • Musculoskeletal pain: This is the most common cause of chest pain in pediatric patients, often related to overuse, trauma, or costochondritis. The pain is typically sharp, localized to the chest wall, and reproducible with palpation or movement.

Other Likely Diagnoses

  • Asthma or other respiratory conditions: Chest pain can be a symptom of asthma, bronchitis, or pneumonia, especially if the pain is associated with coughing, wheezing, or shortness of breath.
  • Gastroesophageal reflux disease (GERD): GERD can cause chest pain in pediatric patients, often accompanied by symptoms like heartburn, regurgitation, or abdominal pain.
  • Precordial catch syndrome: A benign condition characterized by sharp, stabbing chest pain that can be exacerbated by deep breathing or movement.

Do Not Miss Diagnoses

  • Myocardial infarction or cardiac conditions: Although rare in pediatric patients, myocardial infarction or other cardiac conditions like hypertrophic cardiomyopathy, myocarditis, or pericarditis can be life-threatening and require immediate attention.
  • Pulmonary embolism: A rare but potentially fatal condition that can cause sudden onset of chest pain, shortness of breath, and cough.
  • Pneumothorax: A collapsed lung that can cause sudden, severe chest pain and shortness of breath, often requiring emergency intervention.

Rare Diagnoses

  • Sickle cell disease: Patients with sickle cell disease can experience chest pain due to vaso-occlusive crises or other complications.
  • Pneumonia or lung abscess: Bacterial or fungal infections that can cause chest pain, fever, and cough.
  • Tietze's syndrome: A rare condition characterized by inflammation of the cartilages and surrounding tissues of the chest wall, causing chest pain and swelling.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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