From the Guidelines
Dupixent (dupilumab) should be administered by subcutaneous injection at weeks 0,1,2,3, and 4, followed by monthly maintenance dosing, with dosing regimens of 75 mg, 150 mg, or 300 mg, considering discontinuation if no response after 16 weeks of treatment. The dosing for Dupixent (dupilumab) is based on the specific condition being treated and patient factors, but the most recent and highest quality study 1 provides guidance on the administration of the medication. Key points to consider when administering Dupixent include:
- Initial dosing at weeks 0,1,2,3, and 4
- Monthly maintenance dosing thereafter
- Dosing regimens of 75 mg, 150 mg, or 300 mg, with the 300 mg dose given as two injections of 150 mg or one injection of 300 mg
- Consideration of discontinuation if no response is seen after 16 weeks of treatment, as stated in the study 1 When administering Dupixent, it is also important to avoid areas of the skin showing psoriasis, as noted in the study 1. The study 1 from the British Journal of Dermatology in 2024 provides the most recent and highest quality guidance on the dosing and administration of Dupixent.
From the FDA Drug Label
The recommended dosage of DUPIXENT for adult patients is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg given every other week (Q2W).
Dosage in Pediatric Patients 6 Months to 5 Years of Age The recommended dosage of DUPIXENT for pediatric patients 6 months to 5 years of age is specified in Table 1
Dosage in Pediatric Patients 6 Years to 17 Years of Age The recommended dosage of DUPIXENT for pediatric patients 6 years to 17 years of age is specified in Table 2
The recommended dosage of DUPIXENT for adult and pediatric patients 12 years of age and older is specified in Table 3
The recommended dosage of DUPIXENT for pediatric patients 6 to 11 years of age is specified in Table 4
The recommended dosage of DUPIXENT for adult and pediatric patients 12 years of age and older is 300 mg given every other week (Q2W).
The recommended dosage of DUPIXENT for adult and pediatric patients 1 year of age and older, weighing at least 15 kg, is specified in Table 5
The recommended dosage of DUPIXENT for adult patients is an initial dose of 600 mg (two 300 mg injections) followed by 300 mg given every other week (Q2W).
The recommended dosage of DUPIXENT for adult patients is 300 mg given every other week (Q2W).
The dosing for Dupixent (dupilumab) varies based on the indication and patient age:
- Atopic Dermatitis:
- Adults: 600 mg initial dose, followed by 300 mg every other week (Q2W) 2
- Pediatric patients 6 months to 5 years: specified in Table 1
- Pediatric patients 6 years to 17 years: specified in Table 2
- Asthma:
- Adult and pediatric patients 12 years and older: specified in Table 3
- Pediatric patients 6 to 11 years: specified in Table 4
- Chronic Rhinosinusitis with Nasal Polyps: 300 mg every other week (Q2W)
- Eosinophilic Esophagitis: specified in Table 5
- Prurigo Nodularis: 600 mg initial dose, followed by 300 mg every other week (Q2W)
- Chronic Obstructive Pulmonary Disease: 300 mg every other week (Q2W) It is essential to follow the specific dosing recommendations for each indication and age group as outlined in the drug label 2.
From the Research
Dosing Information for Dupixent (Dupilumab)
- The standard dosing regimen for Dupixent is 300 mg every 2 weeks 3, 4, 5.
- In some cases, a patient-centered dosing regimen may be used, which can involve prolonging the dupilumab interval by 50% (300 mg/4 weeks) or 66%-75% (300 mg/6-8 weeks) 6.
- The dosing regimen may vary depending on the patient's condition and response to treatment, with some patients requiring a higher or lower dose 5, 6.
- For pediatric patients with atopic dermatitis, the dosing regimen is not explicitly stated in the provided studies, but the treatment has been shown to be effective in improving asthma and reducing aeroallergen sensitization 7.
Specific Conditions and Dosing
- For moderate-to-severe atopic dermatitis, the standard dosing regimen is 300 mg every 2 weeks 3, 4.
- For moderate-to-severe asthma, the standard dosing regimen is 200 or 300 mg every 2 weeks 5.
- For patients with controlled atopic dermatitis, a patient-centered dosing regimen may be used to reduce the dose and prolong the treatment interval 6.