From the Research
Definition of GLP-1
- GLP-1, or Glucagon-like peptide-1, is a secreted peptide that plays a key role in blood glucose homeostasis 1.
- It is a 30-amino acid peptide hormone produced in the intestinal epithelial endocrine L-cells by differential processing of proglucagon 2.
Functions of GLP-1
- GLP-1 slows gastric emptying, enhances pancreatic insulin secretion, and suppresses pancreatic glucagon secretion 1.
- It stimulates insulin secretion, inhibits glucagon secretion, and contributes to limiting postprandial glucose excursions 2.
- GLP-1 also inhibits gastrointestinal motility and secretion, acts as an enterogastrone, and is part of the "ileal brake" mechanism 2.
- Additionally, GLP-1 appears to be a physiological regulator of appetite and food intake 2.
GLP-1 Microdosing
- There is no direct evidence in the provided studies to define GLP-1 microdosing.
- However, the studies discuss the use of GLP-1 receptor agonists, which are biochemically modified for enhanced potency and sustained action, and are successfully used in clinical practice for the treatment of type-2 diabetes 3.
- The therapeutic effects of GLP-1 receptor agonists are not entirely congruent with the physiological actions of GLP-1, and the relationships between these effects are not fully understood 4.
Therapeutic Applications of GLP-1
- GLP-1 or GLP-1 receptor agonists are being evaluated for the therapy of type 2 diabetes 1, 5, 3.
- GLP-1-based pharmacotherapies are also in clinical evaluation for the treatment of obesity 3.
- GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions, making it an interesting candidate for the development of pharmacotherapies to treat various diseases 3.