From the Guidelines
The fibrin network in PRF is contained within the fibrin clot that forms when platelet-rich fibrin (PRF) is created, which entraps regenerative cells, leukocytes, and growth factors, facilitating the slow and gradual release of growth factors. This process is crucial for the therapeutic properties of PRF, as it allows for the sustained release of bioactive molecules and provides structural support for tissue regeneration 1. The formation of this fibrin clot is a result of the natural coagulation process that occurs when blood is centrifuged without anticoagulants, leading to the conversion of fibrinogen to fibrin by thrombin. Key characteristics of the fibrin network in PRF include:
- Its ability to entrap platelets, leukocytes, and growth factors
- Its role in facilitating the gradual release of these bioactive molecules over time
- Its unique structure, which distinguishes PRF from other platelet concentrates like PRP (Platelet-Rich Plasma) and gives PRF its superior regenerative potential in various clinical applications, such as bone augmentation procedures 1. The use of PRF in these procedures has been shown to promote angiogenesis and soft tissue healing, although current evidence is inconclusive regarding its ability to directly promote bone formation 1.
From the Research
Component of Platelet-rich Fibrin (PRF) Containing the Fibrin Network
- The fibrin network in PRF is formed by the polymerization of fibrinogen, which is activated by thrombin 2.
- The slow polymerization during PRF preparation generates a fibrin network very similar to the natural one, leading to a more efficient cell migration and proliferation 3.
- The fibrin network is the primary protein component in clots and provides a scaffold for infiltrating cells during tissue repair 2.
- The microstructure of PRF appears as two zones, the zone of platelets and the zone of fibrin, which resembles a mesh containing blood cells 4.
- The zone of fibrin in PRF contains a fibrin network that is organized in a specific manner, with increasing density and organization towards the distal region 5.