From the Research
Butyrate supplementation may help manage multiple sclerosis (MS) symptoms by reducing inflammation and supporting gut health, as suggested by recent studies 1, 2. The relationship between butyrate and MS symptoms is an area of ongoing research, with emerging evidence suggesting a potential link between gut health and MS pathology.
Key Findings
- Recent studies have highlighted the importance of gut microbiota in MS pathophysiology, with disease-modifying therapies (DMTs) exerting a parallel effect on the gut microenvironment 1.
- Targeting gut microbiota has been proposed as a new therapeutic opportunity in MS, with potential benefits for reducing inflammation and modulating immune responses 2.
- Butyrate, a short-chain fatty acid, has been shown to have anti-inflammatory properties and may help support gut health by inhibiting histone deacetylases and strengthening the gut barrier.
Recommendations
- Sodium butyrate or tributyrin supplements may be considered at doses of 600-900mg daily, divided into 2-3 doses with meals, although more research is needed to confirm their efficacy and safety in MS patients.
- Increasing dietary butyrate through consumption of fiber-rich foods, such as whole grains, legumes, and vegetables, may also be beneficial, as these foods promote butyrate production by gut bacteria.
- Fermented foods like sauerkraut and kimchi may also help support gut health and potentially reduce MS symptoms.
Important Considerations
- Butyrate supplementation should complement, not replace, conventional MS treatments prescribed by a healthcare provider.
- Patients should consult with their healthcare provider before starting any supplement regimen, especially if they have other health conditions or take medications.
- More research is needed to fully understand the relationship between butyrate and MS symptoms, and to determine the optimal dosage and duration of butyrate supplementation for MS patients.