What is the recommended dosage of Tinnicar (Tinidazole)?

Recommended Dosage of Tinidazole (Tinnicar)

The recommended dosage of tinidazole (Tinnicar) varies by indication, with the standard adult dose being 2 g orally in a single dose for trichomoniasis and giardiasis, 2 g daily for 3 days for intestinal amebiasis, and 2 g daily for 3-5 days for amebic liver abscess. 1

Dosage by Indication

Trichomoniasis

• Adults and adolescents: 2 g orally in a single dose 1
• Should be taken with food to minimize gastrointestinal side effects
• Sexual partners should be treated simultaneously with the same dose 2

Giardiasis

• Adults: 2 g orally in a single dose 1
• Children >3 years: 50 mg/kg (up to 2 g) as a single dose 1
• Should be taken with food

Amebiasis

• Intestinal amebiasis:

  • Adults: 2 g orally once daily for 3 days 1
  • Children >3 years: 50 mg/kg/day (up to 2 g) for 3 days 1

• Amebic liver abscess:

  • Adults: 2 g orally once daily for 3-5 days 1
  • Children >3 years: 50 mg/kg/day (up to 2 g) for 3-5 days 1
  • Children should be closely monitored when treatment exceeds 3 days 1

Bacterial Vaginosis

• Adults: Either 2 g orally once daily for 2 days OR 1 g orally once daily for 5 days 1
• Not studied in pregnant patients for this indication 1

Administration Guidelines

• Take with food to minimize epigastric discomfort and other gastrointestinal side effects 1
• Food does not affect the oral bioavailability of tinidazole 1
• Avoid alcoholic beverages during treatment and for 3 days afterward 1

For Patients Unable to Swallow Tablets

Tinidazole tablets may be crushed in artificial cherry syrup:

1. Pulverize tablets with mortar and pestle
2. Add approximately 10 mL of cherry syrup and mix until smooth
3. Transfer to graduated amber container
4. Rinse mortar with cherry syrup to transfer any remaining drug
5. Final volume should be 30 mL
6. Suspension is stable for 7 days at room temperature
7. Shake well before each administration 1

Clinical Efficacy Considerations

Tinidazole has demonstrated high efficacy in the treatment of protozoal infections with cure rates generally exceeding 90% 3. In comparative studies, tinidazole has shown equivalent or superior efficacy to metronidazole:

• For intestinal amebiasis, tinidazole demonstrated significantly higher cure rates (90-96.5%) compared to metronidazole (53.3-55.5%) when both were administered as 2 g once daily for 3 days 4, 5
• Tinidazole's longer half-life (12.3 hours vs. 7.3 hours for metronidazole) may contribute to its efficacy in single-dose regimens 6, 3

Common Side Effects

• Bitter taste
• Nausea
• Abdominal discomfort
• Anorexia
• Vomiting
• Fatigue 3

Special Considerations

• No dose adjustment necessary based on race, sex, or renal function 3
• Not recommended in patients with severe hepatic impairment (Child-Pugh class C) 3
• For treatment failures in trichomoniasis, consider metronidazole 500 mg twice daily for 7 days 2

Tinidazole's pharmacokinetic profile, with its longer half-life and higher serum levels at 48-72 hours post-dose compared to metronidazole, makes it particularly suitable for once-daily dosing regimens 7.