Vulvovaginal Candidiasis: This is the most common cause of vaginal irritation, especially in women of reproductive age. It is characterized by itching, burning, and a white, clumpy discharge.

Bacterial Vaginosis (BV): BV is another common cause of vaginal irritation, often presenting with a fishy odor and thin, grayish discharge. It results from an imbalance of the normal vaginal flora.
Trichomoniasis: A sexually transmitted infection caused by the parasite Trichomonas vaginalis, leading to symptoms like itching, burning, and a frothy, greenish-yellow discharge.
Atrophic Vaginitis: Common in postmenopausal women due to decreased estrogen levels, leading to vaginal dryness, itching, and burning.

Herpes Simplex Virus (HSV): Although less common, genital herpes can cause significant vaginal irritation along with painful blisters or ulcers. Missing this diagnosis could lead to complications like increased risk of HIV transmission and neonatal herpes.
Syphilis: Another sexually transmitted infection that can cause vaginal irritation among other symptoms. If left untreated, syphilis can lead to serious health problems.
Cervical Cancer: While rare, advanced cervical cancer can cause vaginal irritation. Regular screening is crucial for early detection.

Lichen Sclerosus: A rare condition that creates patchy, white skin that's thinner than normal. It can cause itching and discomfort in the vaginal area.
Lichen Planus: An inflammatory condition that can affect the skin and mucous membranes, including the vagina, leading to irritation and discomfort.
Desquamative Inflammatory Vaginitis (DIV): A rare condition characterized by a significant inflammatory response, leading to vaginal irritation and a purulent discharge.