What is a Trio Smart Test and where can I obtain it or the lactulose (lactulose) breath test preparation?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 13, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

The TRIO Smart Breath Test is a diagnostic tool used to detect small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO) by measuring hydrogen, methane, and hydrogen sulfide gases in your breath, and it can be obtained through a healthcare provider or purchased directly from the manufacturer or authorized distributors. To obtain the TRIO Smart Test or the lactulose breath test preparation, you can contact your healthcare provider who can order it for you, or you can purchase it directly from the manufacturer, Gemelli Biotech, or authorized distributors like Commonwealth Diagnostics International 1. Some functional medicine practitioners and gastroenterologists also offer it in their offices.

Key Points to Consider

  • The lactulose solution needed for the test is typically included in the test kit 1.
  • Before taking the test, you'll drink the lactulose solution (a non-digestible sugar) and then collect breath samples at specific intervals by blowing into tubes.
  • The bacteria in your intestines ferment the lactulose, producing gases that are measured to determine if you have bacterial overgrowth.
  • This test is valuable because it helps identify specific gas patterns that can guide treatment approaches for digestive symptoms like bloating, abdominal pain, diarrhea, or constipation.

Important Considerations

  • The sensitivity and specificity of breath tests, including the lactulose hydrogen breath test, have been found to be poor in some studies, with sensitivities ranging from 17% to 68% and specificities ranging from 70% to less than 70% 1.
  • However, the TRIO Smart Breath Test measures not only hydrogen but also methane and hydrogen sulfide gases, which may provide more accurate results.
  • It is essential to consult with a healthcare provider to determine the best course of action and to interpret the results of the test.

Where to Obtain the Test

  • Healthcare provider
  • Manufacturer (Gemelli Biotech)
  • Authorized distributors (Commonwealth Diagnostics International)
  • Functional medicine practitioners
  • Gastroenterologists

From the Research

Trio Smart Test and Lactulose Breath Test

  • The Trio Smart Test is not explicitly mentioned in the provided studies, but the lactulose breath test is discussed in several studies as a method for detecting small intestinal bacterial overgrowth (SIBO) and evaluating orocecal transit time (OCTT) 2, 3, 4, 5, 6.
  • The lactulose breath test involves the ingestion of lactulose, a non-absorbable carbohydrate, which is fermented by bacteria in the gut, producing hydrogen gas that can be measured in the breath 2, 3, 4, 5, 6.

Obtaining the Lactulose Breath Test

  • The studies do not provide information on where to obtain the lactulose breath test or the Trio Smart Test, but it is likely that the test can be performed in a medical setting, such as a hospital or clinic, under the supervision of a healthcare professional.
  • The lactulose breath test typically involves the ingestion of a specific dose of lactulose, such as 10g or 20g, and the measurement of breath hydrogen levels over a period of time, usually 2-3 hours 2, 4, 5, 6.

Preparation for the Lactulose Breath Test

  • The preparation for the lactulose breath test may involve fasting or avoiding certain foods and medications before the test, but the specific preparation instructions are not provided in the studies.
  • The studies suggest that the lactulose breath test can be influenced by various factors, such as intestinal and extraintestinal factors, and that the results should be interpreted with caution 2, 3, 4, 5, 6.

Related Questions

What is the preferred substrate, lactulose or glucose, for the Small Intestine Bacterial Overgrowth (SIBO) breath test in terms of accuracy?
What is the management approach for a patient with elevated baseline hydrogen breath test results, indicating potential small intestine bacterial overgrowth (SIBO) or other gastrointestinal conditions, who cannot proceed with testing?
What is the purpose of the Lactulose (lactulose) breath test?
What is the diagnostic test for Small Intestine Bacterial Overgrowth (SIBO)?
What types of malabsorption are diagnosed using D-xylose, lactulose with hydrogen breath test, fecal elastase, Sudan (stain) test, and SeHCAT (tauroselcholic acid scan)?
What is a Trio Smart Test (Non-Invasive Prenatal Test) and where can a patient undergo one?
Can a 7-year-old immunocompromised patient with Herpes Simplex Virus-1 (HSV-1) Encephalitis develop resistance to Acyclovir (antiviral) after 15 days of treatment, complicated by intracranial hemorrhage and pneumonia?
Can a 71-year-old immunocompromised patient with Herpes Simplex Virus-1 (HSV-1) Encephalitis develop resistance to Acyclovir (antiviral) after 15 days of treatment, complicated by intracranial hemorrhage and pneumonia?
What are the treatment options for atopic dermatitis (eczema)?
Is there a blue methenamine (methenamine) tablet with a smooth coating?
What is the management for a 56-year-old female with recurrent otalgia and hearing loss in the ear, who has a history of tympanostomy tube (ear tube) insertion after swimming without earplugs?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.