From the Guidelines
Allulose has been shown to have a minimal impact on blood glucose levels, and its consumption may actually reduce post-meal blood glucose spikes by inhibiting intestinal alpha-glucosidase enzymes and enhancing GLP-1 secretion. The evidence for the benefits of allulose on blood glucose levels is not directly addressed in the provided studies 1. However, these studies discuss the effects of various sugars and sweeteners on blood glucose levels.
Key Points
- The studies suggest that sugar alcohols, which include allulose, produce a lower postprandial glucose response than fructose, sucrose, or glucose and have lower available energy values 1.
- The use of sugar alcohols appears to be safe, although they may cause diarrhea, especially in children 1.
- The FDA has approved several non-nutritive sweeteners for use in the U.S., but allulose is not explicitly mentioned in the provided studies 1.
- The American Diabetes Association recommends that people with diabetes choose nutrient-dense, high-fiber foods whenever possible and avoid sugary drinks and foods with added sugars 1.
Recommendations
Based on the available evidence, allulose may be a suitable alternative to sugar for people with diabetes or those who want to manage their blood glucose levels. However, it is essential to consume allulose in moderation and as part of a balanced diet. Typical effective doses of allulose range from 5-15 grams per day, and studies have shown benefits at these levels without significant side effects. It is crucial to note that allulose is not a replacement for medication or lifestyle modifications, and people with diabetes should consult their healthcare provider before making any changes to their diet or treatment plan.
Future Research
More research is needed to fully understand the effects of allulose on blood glucose levels and its potential benefits for people with diabetes. Studies should investigate the optimal dosage and duration of allulose consumption, as well as its effects on glucose metabolism and insulin sensitivity. Additionally, research should explore the potential interactions between allulose and other medications or supplements, such as metformin or GLP-1 receptor agonists.
From the Research
Benefits of Allulose on Blood Glucose Levels
The evidence suggests that allulose has a positive effect on blood glucose levels.
- A study published in 2021 found that D-allulose was associated with a dose-dependent reduction of plasma glucose at 30 min compared with placebo 2.
- Another study published in 2023 found that a diabetic diet containing 8.5 g of D-allulose improved peak postprandial blood glucose levels in type 2 diabetes patients compared with a strictly energy-controlled diabetic diet 3.
- A systematic review and meta-analysis published in 2023 found that D-allulose attenuates postprandial blood glucose concentrations in healthy humans 4.
- A 12-week study published in 2024 found that allulose supplementation improved body weight, insulin sensitivity, and glycemic control in a rat model of diet-induced obesity and type 2 diabetes 5.
Key Findings
- D-allulose has been shown to reduce plasma glucose levels in a dose-dependent manner 2.
- Allulose-containing diets have been found to improve postprandial blood glucose levels in type 2 diabetes patients 3.
- D-allulose has been found to attenuate postprandial blood glucose concentrations in healthy humans 4.
- Allulose supplementation has been found to improve metabolic health markers, including body weight, insulin sensitivity, and glycemic control 5.
Contrasting Findings
- A study published in 2018 found that small doses of fructose or allulose did not show a significant effect on plasma glucose incremental area under the curve in response to a 75 g-oral glucose tolerance test in healthy individuals 6.