Treatment Options for Temporal Arteritis
High-dose systemic glucocorticoids are the cornerstone of treatment for temporal arteritis and should be initiated promptly to prevent vision loss and other serious complications. 1
Initial Treatment
First-line Therapy
- Immediate high-dose glucocorticoids:
- Prednisone 50 mg daily for one month is recommended to suppress arterial inflammation and preserve vision 1
- This high dose is necessary to quickly control inflammation and prevent irreversible complications
- Do not wait for biopsy results if clinical suspicion is high
Monitoring and Dose Adjustment
- After the initial month of high-dose therapy, taper the dose according to symptoms
- Do not taper based solely on erythrocyte sedimentation rate (ESR) 1
- Regular monitoring should include:
- Assessment of clinical symptoms (headache, visual changes, jaw claudication)
- Physical examination
- Inflammatory markers (ESR, CRP)
Long-term Management
Glucocorticoid Tapering
- Gradual tapering is essential to prevent relapse
- Treatment may need to be continued for several years 1
- Taper schedule should be individualized based on symptom control and inflammatory marker trends
Steroid-sparing Agents
- Consider adding steroid-sparing agents in cases of:
- Steroid-related adverse effects
- Inability to taper steroids
- Relapsing disease
Monitoring for Complications
- Regular assessment for steroid-related adverse effects:
- Osteoporosis
- Diabetes
- Hypertension
- Cataracts
- Increased susceptibility to infections
Symptomatic Relief
- NSAIDs may provide additional symptomatic relief but should be used with caution 2
- NSAIDs should be used:
- At the minimum effective dose
- For the shortest time possible
- After evaluation of gastrointestinal, renal, and cardiovascular risks 3
Important Considerations
Potential Pitfalls
- Delayed treatment: Vision loss can occur rapidly and may be permanent if treatment is delayed
- Inadequate initial dosing: Underdosing steroids initially may fail to control inflammation
- Too-rapid tapering: Can lead to disease flares and complications
- Relying solely on ESR for treatment decisions: Clinical symptoms should guide therapy adjustments
Special Populations
- Elderly patients: Require careful monitoring for steroid-related complications
- Patients with comorbidities: May need additional treatments to manage steroid-related side effects
Follow-up Care
- Regular follow-up visits are essential to:
- Assess treatment response
- Monitor for disease recurrence
- Manage medication side effects
- Adjust treatment as needed
Temporal arteritis is a medical emergency that requires prompt diagnosis and treatment. The primary goal is to prevent vision loss and other ischemic complications through immediate initiation of high-dose glucocorticoids, followed by a carefully monitored tapering schedule over an extended period.