What are the diagnostic criteria for Post-Traumatic Stress Disorder (PTSD)?

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Last updated: September 11, 2025View editorial policy

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Diagnostic Criteria for Post-Traumatic Stress Disorder (PTSD)

The diagnostic criteria for PTSD include exposure to a traumatic event followed by symptoms across four distinct clusters: intrusion/re-experiencing, avoidance, negative alterations in cognition and mood, and increased arousal and reactivity, which persist for at least one month and cause significant functional impairment. 1

Core Diagnostic Requirements

1. Trauma Exposure

  • Exposure to actual or threatened death, serious injury, or sexual violence through:
    • Direct experience
    • Witnessing the event
    • Learning about the event occurring to a close family member/friend
    • Experiencing repeated or extreme exposure to aversive details of traumatic events

2. Symptom Clusters (must persist for at least 1 month)

A. Intrusion/Re-experiencing

  • Recurrent, involuntary, and intrusive distressing memories
  • Traumatic nightmares
  • Dissociative reactions (flashbacks) where the person feels or acts as if the event is recurring
  • Intense or prolonged psychological distress at exposure to trauma-related cues
  • Marked physiological reactions to trauma-related stimuli 2

B. Avoidance

  • Persistent avoidance of distressing memories, thoughts, or feelings related to the trauma
  • Avoidance of external reminders (people, places, conversations, activities) that arouse distressing memories 2

C. Negative Alterations in Cognition and Mood

  • Inability to remember important aspects of the traumatic event
  • Persistent negative beliefs about oneself, others, or the world
  • Distorted thoughts about the cause or consequences leading to self-blame or blame of others
  • Persistent negative emotional state
  • Diminished interest in significant activities
  • Feelings of detachment or estrangement from others
  • Persistent inability to experience positive emotions 2, 1

D. Increased Arousal and Reactivity

  • Irritable behavior and angry outbursts
  • Reckless or self-destructive behavior
  • Hypervigilance
  • Exaggerated startle response
  • Problems with concentration
  • Sleep disturbance 2, 1

3. Duration and Impairment

  • Symptoms persist for more than one month
  • Symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning 1, 3

Assessment Tools

  • PTSD Checklist for DSM-5 (PCL-5) is recommended to track progress across specific symptom clusters 1, 3
  • Structured clinical interviews can provide more comprehensive assessment 4

Differential Diagnosis Considerations

  • Acute Stress Disorder (similar symptoms but duration less than one month)
  • Adjustment Disorder
  • Major Depressive Disorder
  • Anxiety Disorders
  • Substance-induced disorders 1, 3

Special Considerations

Complex PTSD

  • Recognized in ICD-11 but not in DSM-5
  • Characterized by the core features of PTSD plus severe and persistent disturbances in:
    • Affect regulation
    • Negative self-concept
    • Difficulties in sustaining relationships 2

Cultural Factors

  • Cultural syndromes may influence symptom presentation and attribution
  • Cultural background affects how individuals perceive and report trauma-related symptoms
  • Assessment should consider cultural variations in the expression of distress 2, 1

Comorbidities

  • High rates of comorbidity with mood disorders, anxiety disorders, and substance use disorders
  • These comorbidities should be assessed and treated concurrently for optimal outcomes 1, 3, 5

Prevalence and Risk

  • Lifetime prevalence of approximately 6-10% in the general population
  • More than 70% of adults worldwide experience at least one traumatic event in their lifetime
  • Approximately 10% of individuals develop PTSD after experiencing a traumatic event 3, 5

Understanding these diagnostic criteria is essential for accurate identification and appropriate treatment planning for individuals suffering from PTSD, which typically includes trauma-focused psychotherapy as first-line treatment, with medication as an adjunctive approach when needed.

References

Guideline

Post-Traumatic Stress Disorder (PTSD) Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Posttraumatic Stress Disorder: Evaluation and Treatment.

American family physician, 2023

Research

Post-traumatic Stress Disorder.

The Medical clinics of North America, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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