What is the cause of white skin on the penis, also known as leukoderma (hypopigmentation) of the penis?

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Differential Diagnosis for White Skin on the Penis

  • Single most likely diagnosis
    • Lichen sclerosus: This condition is characterized by white, patchy skin that can become thin and wrinkled, often affecting the genital area. It's a common cause of white skin on the penis and can be managed with topical corticosteroids.
  • Other Likely diagnoses
    • Vitiligo: An autoimmune condition that causes loss of skin pigment, leading to white patches. While it can occur anywhere on the body, it's less common on the penis compared to other areas.
    • Eczema (atopic dermatitis): Can cause white, scaly patches due to inflammation and skin dryness. Genital eczema is less common but can occur.
    • Psoriasis: Although less common in the genital area, psoriasis can cause white, scaly patches due to an overactive immune response.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Squamous cell carcinoma: A type of skin cancer that can present as white or discolored patches. Early detection is crucial for effective treatment.
    • Extramammary Paget's disease: A rare skin cancer that can appear as white or red patches in the genital area, requiring prompt medical attention.
  • Rare diagnoses
    • Scleroderma: A chronic autoimmune disease that can cause skin thickening and hardening, potentially leading to white, tight skin on the penis.
    • Pityriasis alba: A mild skin condition causing small, round, white patches due to mild eczema or dry skin, more common in children but can occur in adults.
    • Leukoplakia: A condition characterized by white patches on mucous membranes, which can rarely occur on the penis and may be associated with an increased risk of cancer.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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