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Last updated: September 11, 2025View editorial policy

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Differential Diagnosis for Left Toe Burning

  • Single most likely diagnosis
    • Peripheral neuropathy: This is a common condition that can cause burning sensations in the toes due to damage to the peripheral nerves. It can be caused by various factors such as diabetes, vitamin deficiencies, or trauma.
  • Other Likely diagnoses
    • Morton's neuroma: A condition where a nerve in the foot becomes irritated, causing burning or sharp pain, typically between the toes.
    • Poor circulation: Reduced blood flow to the toes can cause burning sensations, often accompanied by coldness or numbness.
    • Gout or other arthritis: Inflammatory conditions that can cause burning pain in the toes, especially if a joint is affected.
    • Ingrown toenail: A condition where the nail grows into the surrounding skin, causing pain, redness, and sometimes a burning sensation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Deep vein thrombosis (DVT): A blood clot in the deep veins of the leg can cause burning pain, swelling, and warmth, and can be life-threatening if it breaks loose and travels to the lungs.
    • Cellulitis or abscess: Bacterial infections of the skin and soft tissues can cause burning pain, redness, and swelling, and can lead to serious complications if not treated promptly.
    • Complex regional pain syndrome (CRPS): A chronic pain condition that can cause burning sensations, usually after an injury or trauma, and can be debilitating if not properly managed.
  • Rare diagnoses
    • Erythromelalgia: A rare disorder that causes burning pain, heat, and redness in the hands and feet, often accompanied by an increased heart rate.
    • Fabry disease: A genetic disorder that can cause burning sensations in the hands and feet, as well as other systemic symptoms.
    • Peripheral artery disease (PAD): A condition where the arteries that supply blood to the legs become narrowed, causing burning pain, cramping, and weakness in the legs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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