What is the treatment for Cannabis (Marijuana) intoxication?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 14, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

The treatment for Cannabis (Marijuana) intoxication primarily involves supportive care in a calm and supportive environment, with no specific medication recommended for the treatment of withdrawal, but symptomatic medication may be used to relieve symptoms such as agitation or sleep disturbance. When considering the management of cannabis intoxication, it's essential to focus on alleviating symptoms rather than attempting to reverse the intoxication, as there is no specific antidote for THC 1. The approach to treatment can be broken down into several key components:

  • Providing a supportive environment to help manage the psychological effects of intoxication
  • Relieving symptoms such as agitation or sleep disturbance with symptomatic medication, if necessary
  • Monitoring for less common but more severe effects like depression or psychosis, and seeking specialist advice if these occur 1
  • Ensuring the individual is hydrated and rested, as these can help mitigate some of the physical symptoms of intoxication It's also important to note that cannabis intoxication is generally temporary, with most effects resolving within a certain timeframe as the body metabolizes the compounds. In cases where symptoms are severe, medical attention may be required to manage them appropriately and prevent any potential complications. However, the core principle of treatment remains centered on supportive care, emphasizing the importance of a calm environment and symptom management 1.

From the Research

Treatment for Cannabis (Marijuana) Intoxication

The treatment for cannabis intoxication can be divided into several approaches:

  • Supportive care: This is the most important aspect of treatment and should precede specific antitoxin treatments 2.
  • Pharmacological interventions: These include beta-blockers, antiarrhythmic agents, antagonists of CB-1 and GABA-benzodiazepine receptors, antipsychotics, and cannabidiol 3.
  • Symptomatic treatment: This approach focuses on treating the specific symptoms of cannabis intoxication, such as anxiety, psychosis, and cognitive dysfunction 3.
  • Neuroleptic treatment: This has been shown to be effective in attenuating psychotic symptoms within five days of the initiation of the episode 4.

Management of Intoxication

The management of cannabis intoxication involves:

  • Establishing an accurate diagnosis and prognosis 5.
  • Providing a quiet, safe, and reassuring environment 6.
  • Closely monitoring vital signs and promptly treating any changes in blood pressure, respiratory frequency, and temperature 6.
  • Administering intravenous fluids as soon as possible 6.
  • Considering the use of antidotes, such as propanolol and rimonabant, although further studies are needed to establish their effectiveness 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Initial diagnosis and treatment for poisoning].

Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2013

Research

Cannabis psychosis following bhang ingestion.

British journal of addiction, 1991

Research

An approach to the management of the poisoned patient.

Archives of internal medicine, 1986

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.