Amphetamine Base Content in Danavly XR
Danavly XR does not contain amphetamine base. It is not a recognized FDA-approved ADHD medication in the current pharmacopeia.
Understanding ADHD Medication Formulations
Based on the available evidence, there is no medication called "Danavly XR" in the current guidelines or FDA-approved medications for ADHD treatment. The guidelines from the American Academy of Child and Adolescent Psychiatry and American Academy of Pediatrics mention several FDA-approved stimulant medications for ADHD 1, including:
- Methylphenidate-based products
- Amphetamine-based products such as:
- Adderall XR
- Vyvanse (lisdexamfetamine)
- Other amphetamine formulations
Amphetamine Content in Known ADHD Medications
For reference, FDA-approved amphetamine-based medications typically contain:
- Mixed amphetamine salts (as in Adderall XR) - containing both dextroamphetamine and levoamphetamine salts
- Lisdexamfetamine (Vyvanse) - a prodrug that is metabolized to dextroamphetamine
- Dextroamphetamine formulations
The typical starting doses for amphetamine-based medications range from 5-10 mg daily with maximum daily doses up to 50 mg 1.
Pharmacological Properties of Amphetamines
Amphetamines are sympathomimetic amines with a beta-phenylisopropylamine structure 2. They have:
- Good oral bioavailability
- High distribution volume (4 L/kg)
- Low plasma protein binding (less than 20%)
- Elimination half-life of 6-12 hours
- Both hepatic and renal clearance contribute to elimination 3
Clinical Considerations for Amphetamine Medications
When prescribing amphetamine-based medications, it's important to be aware that:
- Amphetamines increase systolic blood pressure by approximately 1.93 mmHg and diastolic blood pressure by 1.84 mmHg compared to placebo 4
- They also increase heart rate by approximately 3.71 beats per minute 4
- These cardiovascular effects appear to be sustained with long-term use 4
Conclusion
If you are seeking information about a specific ADHD medication, I recommend consulting with a healthcare provider or pharmacist about FDA-approved options. The name "Danavly XR" does not appear in current medical literature or guidelines for ADHD treatment.