From the Research
Relationship Between Ferritin and Interleukin-1 beta (IL-1β) and Interferon-stimulated gene 18 (ISG18)
- The relationship between low ferritin levels and low IL-1β and ISG18 is not directly addressed in the provided studies 1, 2, 3, 4, 5.
- However, the studies suggest that ferritin levels are associated with inflammatory responses and cytokine regulation, including IL-1β and other interleukins 1, 2, 3, 4, 5.
- For example, a study found that low-dose IL-2 subcutaneous immunotherapy decreased ferritin mean levels and increased transferrin values in cancer patients 1.
- Another study found that elevated ferritin levels were associated with raised levels of IL-1β and IL-18 in patients with AA amyloidosis 2.
- A more recent study found that elevated ferritin levels, mediated by IL-18, were associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS) 3.
- Additionally, a study found that high levels of ferritin, IL-18, and sCD163 receptor were associated with "hyperferritinemic syndrome" in COVID-19 patients, but no significant correlation was found between the rise of ferritin and the levels of sCD163 or IL-18 4.
- Furthermore, a study found that pro-inflammatory cytokines, including IL-1β, TNFα, and IFNγ, modulated iron metabolism in a monocyte cell line, affecting transferrin uptake, iron handling, and ferritin mRNA expression 5.
Cytokine Regulation of Iron Metabolism
- The studies suggest that cytokines, including IL-1β, play a role in regulating iron metabolism and ferritin levels 1, 2, 3, 4, 5.
- For example, IL-1β was found to decrease transferrin-iron uptake and affect the proportion of iron associated with ferritin in a monocyte cell line 5.
- Additionally, IL-18 was found to mediate the association between elevated ferritin levels and systemic inflammation and mortality in ARDS 3.