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Last updated: September 12, 2025View editorial policy

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Differential Diagnosis for Rash Resembling Molluscum Contagiosum with Open Skin

  • Single Most Likely Diagnosis
    • Molluscum contagiosum: This is the most likely diagnosis given the description of the rash. Molluscum contagiosum is a viral infection that causes small, pearly, or flesh-colored bumps on the skin, which can sometimes have a central depression or opening, especially if scratched or picked at.
  • Other Likely Diagnoses
    • Folliculitis: An infection of the hair follicles, which can cause small, pus-filled bumps that might resemble molluscum contagiosum, especially if the skin is open or irritated.
    • Keratosis pilaris: A condition that causes rough patches and small, acne-like bumps on the skin, which could be mistaken for molluscum contagiosum, particularly if the skin is dry and irritated.
    • Warts: Caused by the human papillomavirus (HPV), warts can appear as small, rough growths on the skin and might be confused with molluscum contagiosum, especially if they become irritated or open.
  • Do Not Miss Diagnoses
    • Cutaneous lymphoma (e.g., mycosis fungoides): Although rare, cutaneous lymphomas can present with a variety of skin lesions, including those that might resemble molluscum contagiosum. Missing this diagnosis could have severe consequences due to the potential for progression and the need for specific treatment.
    • Leishmaniasis: A parasitic infection that can cause skin lesions, which might appear similar to molluscum contagiosum, especially in travelers or individuals exposed to certain regions where the disease is endemic. It requires specific treatment to prevent complications.
  • Rare Diagnoses
    • Cryptococcosis: A fungal infection that can cause skin lesions, among other symptoms, particularly in immunocompromised individuals. While rare, it's a consideration in patients with weakened immune systems.
    • Histoplasmosis: Another fungal infection that can cause a variety of symptoms, including skin lesions, mainly in immunocompromised patients or those exposed to the fungus through environmental contact.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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