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Last updated: September 13, 2025View editorial policy

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Differential Diagnosis for Cheek Tingling

  • Single most likely diagnosis
    • Trigeminal Neuralgia: This condition is characterized by sudden, severe, and sharp pain or tingling in parts of the face, including the cheeks, due to irritation of the trigeminal nerve. The symptoms can be triggered by light touch or even a gentle breeze on the face.
  • Other Likely diagnoses
    • Multiple Sclerosis: This autoimmune disease can cause a wide range of neurological symptoms, including numbness, tingling, or weakness in various parts of the body, including the face. Cheek tingling could be a manifestation of a relapse or an initial symptom.
    • Hyperventilation Syndrome: Deep or rapid breathing can lead to a drop in carbon dioxide levels in the blood, causing tingling sensations around the mouth and in the fingers and toes, including the cheeks.
    • Dental Problems: Issues such as an abscess, impacted tooth, or gum disease can cause referred pain or tingling sensations in the cheek area due to the close proximity of dental nerves to facial nerves.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Stroke or Transient Ischemic Attack (TIA): Although less common, facial tingling can be a symptom of a stroke or TIA, especially if accompanied by other neurological deficits such as weakness, vision changes, or speech difficulties. Prompt recognition and treatment are crucial.
    • Lyme Disease: In its early stages, Lyme disease can cause neurological symptoms, including facial palsy or tingling, especially if the infection spreads to the nerves.
  • Rare diagnoses
    • Sarcoidosis: This inflammatory disease can affect multiple parts of the body, including the nervous system, leading to tingling or numbness in the face among other symptoms.
    • Vitamin Deficiencies (e.g., Vitamin B12 deficiency): Certain vitamin deficiencies can cause neurological symptoms, including tingling sensations in various parts of the body, including the face.
    • Peripheral Neuropathy: Conditions such as diabetes or certain infections can cause damage to the peripheral nerves, leading to tingling, numbness, or pain in the face, although this is less common than in the extremities.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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