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Last updated: September 13, 2025View editorial policy

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Differential Diagnosis for White Patches Between Toes

Single Most Likely Diagnosis

  • Tinea pedis (Athlete's foot): This is the most common fungal infection of the foot, often presenting with white patches or scaling between the toes due to moisture retention and fungal growth.

Other Likely Diagnoses

  • Contact dermatitis: An allergic or irritant reaction to substances like soap, detergent, or certain materials in shoes can cause white patches or skin changes between the toes.
  • Eczema (Dyshidrotic eczema): Characterized by small, itchy blisters or dry, scaly skin, often on the palms or soles, and can appear as white patches between the toes.
  • Hyperhidrosis: Excessive sweating can lead to maceration of the skin, which might appear as white, soft patches between the toes.

Do Not Miss Diagnoses

  • Squamous cell carcinoma: Although rare, skin cancers can present in unusual locations, including between the toes. Any non-healing lesion or unusual skin change warrants further investigation.
  • Lymphoma (Cutaneous T-cell lymphoma): Rarely, lymphoma can present with skin manifestations, including patches or lesions in unusual areas like between the toes.

Rare Diagnoses

  • Pityriasis versicolor: A fungal infection more commonly affecting the trunk, but can occasionally appear on the feet, causing discolored patches.
  • Keratolysis exfoliativa: A condition characterized by the peeling of skin on the palms or soles, which could potentially appear as white patches between the toes.
  • Leukoderma: Areas of skin turning white due to loss of pigment, which could be idiopathic or associated with other conditions, and might rarely present between the toes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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