What are the effects and side effects of Bupropion (Wellbutrin) 75mg from weeks 1 to 8?

Bupropion 75mg Effects and Side Effects: Week 1 to Week 8

Bupropion 75mg typically causes stimulating effects in the first 1-2 weeks with common side effects including insomnia, anxiety, dry mouth, and headache, while therapeutic antidepressant effects generally begin to appear around weeks 2-4 and continue to improve through week 8. 1, 2

Week-by-Week Effects and Side Effects

Weeks 1-2

• Initial Effects:

  • Stimulating properties due to norepinephrine and dopamine reuptake inhibition 1
  • Possible increased energy levels 1
  • Little to no therapeutic antidepressant effect yet 2

• Common Side Effects:

  • Insomnia (especially if taken late in the day) 2
  • Anxiety/jitteriness 1, 2
  • Dry mouth 2
  • Headache 2
  • Nausea 2
  • Dizziness 2

Weeks 3-4

• Therapeutic Effects:

  • Beginning of antidepressant effects 2
  • Increased energy and motivation 1
  • Possible reduction in depressive symptoms 2

• Side Effects:

  • Most initial side effects may begin to diminish 3
  • Insomnia and anxiety may persist in some patients 1, 2
  • Constipation may become more noticeable 2
  • Decreased appetite may lead to initial weight changes 2

Weeks 5-6

• Therapeutic Effects:

  • More consistent improvement in mood 2
  • Better concentration and focus 1
  • Increased energy levels stabilize 1

• Side Effects:

  • Many initial side effects typically diminish significantly 3
  • Some patients may continue to experience dry mouth, constipation 2
  • Blood pressure and heart rate should be monitored during this period 1

Weeks 7-8

• Therapeutic Effects:

  • Full antidepressant effect usually established 2
  • Stable improvement in depressive symptoms 2
  • Better overall functioning 1

• Side Effects:

  • Most patients have adjusted to the medication 3
  • Persistent side effects (if any) are usually mild 2
  • Some patients may notice joint aches 2

Important Monitoring Considerations

• Blood Pressure and Heart Rate:

  • Regular monitoring is necessary, especially during the first 12 weeks 1
  • Bupropion can increase blood pressure and heart rate 1

• Neuropsychiatric Symptoms:

  • Monitor for anxiety, agitation, and insomnia 1, 2
  • Increased vigilance for suicidal thoughts, especially in patients under 24 years 1

• Seizure Risk:

  • The 75mg dose has lower seizure risk than higher doses 1
  • Risk increases with higher doses or when combined with other medications that lower seizure threshold 1

Important Precautions

• Timing of Doses:

  • Take doses at least 24 hours apart 2
  • Take earlier in the day to minimize insomnia 2
  • Do not take close to bedtime if experiencing sleep difficulties 2

• Medication Interactions:

  • Avoid combining with MAOIs 1, 2
  • Use caution with medications metabolized by CYP2D6 3
  • Limit or avoid alcohol during treatment 2

• Contraindications:

  • Seizure disorders 1
  • Eating disorders (anorexia, bulimia) 1
  • Uncontrolled hypertension 1
  • Current use of MAO inhibitors 1, 2

Managing Common Side Effects

• For Insomnia:

  • Take medication earlier in the day 2
  • Practice good sleep hygiene 2

• For Anxiety/Jitteriness:

  • Consider dose reduction if severe 1
  • These symptoms often diminish after the first few weeks 1

• For Dry Mouth:

  • Stay well hydrated 2
  • Use sugar-free gum or lozenges 2

• For Headaches:

  • Usually temporary and resolve within the first few weeks 2
  • Over-the-counter pain relievers may help if approved by your doctor 2

Remember that therapeutic effects of bupropion may take several weeks to become fully apparent, and it's important to continue taking the medication as prescribed even after feeling better 2. If side effects are severe or persistent, consult your healthcare provider before making any changes to your medication regimen.