First Step in Headache Evaluation
The first step when a patient complains of headache is to perform a thorough history taking and physical examination to distinguish between primary and secondary headaches, and to identify red flags that may indicate a more serious underlying condition. 1
Initial Assessment: Focus on Red Flags
When evaluating a patient with headache, prioritize identifying these red flags that warrant urgent attention:
- "Worst headache of life"
- New headache pattern after age 50
- Headache worsened by Valsalva maneuver
- Headache that awakens patient from sleep
- Headache with focal neurological deficits
- Recent head or neck injury
- Abrupt onset headache
- Headache associated with exertion or sexual activity
- Systemic signs/symptoms (fever, weight loss)
- Secondary risk factors (cancer, HIV) 1, 2
Key Components of History Taking
Headache characteristics:
- Location (unilateral vs. bilateral)
- Quality (pulsating, throbbing, pressure)
- Intensity (mild, moderate, severe)
- Duration (hours, days)
- Frequency (episodic vs. chronic)
- Aggravating/alleviating factors
- Associated symptoms (nausea, vomiting, photophobia, phonophobia)
Timing and pattern:
- New vs. recurrent headache
- Acute vs. gradual onset
- Progression pattern
- Relationship to activities or time of day
Focused Neurological Examination
The American Academy of Neurology recommends a complete neuro-ophthalmologic examination including:
- Visual acuity testing
- Visual field testing
- Fundoscopic examination
- Extraocular movement assessment
- Pupillary responses 1
Additionally, perform:
- Mental status assessment
- Cranial nerve examination
- Motor and sensory testing
- Deep tendon reflexes
- Coordination testing
- Meningeal signs
Decision Algorithm After Initial Assessment
Based on the American Academy of Family Physicians recommendations:
If red flags present:
- Urgent neuroimaging (MRI with contrast preferred over CT for non-emergent situations)
- Consider referral to emergency department or neurology
If no red flags and pattern suggests primary headache:
- Classify according to International Headache Society criteria
- Initiate appropriate treatment based on headache type and severity
Common Pitfalls to Avoid
- Failure to identify secondary headaches
- Overlooking medication overuse headache
- Misdiagnosis of migraine
- Inadequate treatment leading to chronic daily headache 1
Remember that while most headaches are benign primary headache disorders, missing a serious secondary cause can lead to significant morbidity and mortality. The history and physical examination are the most critical tools in making this distinction.