From the Research
Use of Nitrate Cream (Nitroglycerin) via the Vaginal Route
- There is limited information available on the use of nitrate cream (nitroglycerin) via the vaginal route in the provided studies 1, 2, 3, 4, 5.
- However, it is known that the vaginal route can be used for systemic drug administration, and it has been explored for the delivery of various therapeutic agents, including hormones and peptides 2, 4.
- The vaginal route offers advantages such as lower doses, steady drug levels, and less frequent administration compared to the oral route, as well as avoidance of gastrointestinal disturbances and the first-pass effect 4.
- Some studies have investigated the use of novel approaches to vaginal drug delivery, including mucoadhesive or bioadhesive polymers, pH- or temperature-sensitive polymers, liposomes, nanoemulsions, nanoparticles, vaginal inserts, multiple emulsions, and hydrogels 2.
- While the provided studies do not specifically address the use of nitrate cream (nitroglycerin) via the vaginal route, they do discuss the use of nitrates in general, including their pharmacology, therapeutic use, and delivery systems 1, 3, 5.