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Last updated: September 14, 2025View editorial policy

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Differential Diagnosis for a 3-Day-Old Infant Who Hasn’t Peed or Pooped Since Yesterday

  • Single Most Likely Diagnosis
    • Dehydration: This is a common issue in newborns, especially if they are not latching well or if there are issues with milk supply. Dehydration can lead to decreased urine output and constipation.
  • Other Likely Diagnoses
    • Normal variation in bowel movements: Newborns, especially breastfed ones, can have a wide range of normal bowel movement patterns. Some may not have a bowel movement every day.
    • Constipation: This can be due to various reasons including diet (if formula-fed), dehydration, or anatomical issues.
    • Urinary tract infection (UTI): Although less common, UTIs can cause decreased urine output and should be considered, especially if other symptoms like fever are present.
  • Do Not Miss Diagnoses
    • Renal agenesis or other renal anomalies: These are congenital conditions where one or both kidneys are absent or not functioning properly. Early detection is crucial for management.
    • Intestinal obstruction: Conditions like pyloric stenosis, intussusception, or Hirschsprung’s disease can cause bowel obstruction leading to no stool passage.
    • Spinal cord anomalies: Issues like spina bifida can affect the nerves controlling bowel and bladder function.
    • Severe infection or sepsis: Infections can cause decreased urine output and bowel movements due to systemic illness.
  • Rare Diagnoses
    • Cystic fibrosis: Although rare, it can present with intestinal obstruction (meconium ileus) in newborns.
    • Hirschsprung’s disease: A congenital condition affecting the large intestine, leading to severe constipation or intestinal obstruction.
    • Prune belly syndrome: A rare condition characterized by the absence of abdominal muscles, undescended testicles, and urinary tract anomalies.

Each of these diagnoses requires careful consideration of the infant's overall clinical presentation, including physical examination findings, feeding patterns, and any additional symptoms such as vomiting, fever, or abdominal distension.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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