What are the active ingredients in Midol (ibuprofen/acetaminophen)?

Active Ingredients in Midol

Midol contains isometheptene, acetaminophen, and dichloralphenazone as its active ingredients. 1

Detailed Composition

Midol is a combination medication specifically formulated for relief of milder migraine headaches and menstrual symptoms. The standard formulation contains:

• Isometheptene - a sympathomimetic amine with vasoconstrictive properties
• Acetaminophen (500 mg) - an analgesic and antipyretic agent
• Dichloralphenazone - a mild sedative

This specific combination is designed to address multiple aspects of pain and discomfort associated with menstrual symptoms or mild migraines.

Mechanism of Action

Each component in Midol serves a specific purpose:

• Acetaminophen (500 mg) - Provides pain relief and reduces fever through central nervous system effects, with minimal anti-inflammatory action 1
• Isometheptene - Constricts dilated blood vessels that may contribute to headache pain
• Dichloralphenazone - Provides mild sedative effects to help with associated discomfort

Dosing Information

The typical dosing for Midol is:

• Initial dose: Two capsules
• Maintenance: One capsule per hour as needed
• Maximum dosage: Five capsules per 12 hours and 20 per month
• Usage limitation: Two days or fewer per week 1

Important Contraindications

Midol should not be used in patients with:

• Hepatic or renal impairment
• Hypertension
• Glaucoma
• Alcoholism
• Cardiac disease
• Use of monoamine oxidase inhibitors (MAOIs) within 14 days 1

Potential Adverse Effects

Common side effects may include:

• Hypertension
• Dizziness
• Skin rash 1

Clinical Considerations

When considering Midol for pain management:

1. Be aware that acetaminophen has a maximum recommended daily dose of 4000 mg to prevent liver toxicity 1
2. The FDA has issued warnings about acetaminophen's potential for liver damage, particularly when combined with other acetaminophen-containing products 1
3. Patients should be cautioned against using multiple products containing acetaminophen simultaneously to avoid exceeding safe daily limits

Alternative Options

For patients who cannot take Midol due to contraindications, alternative options include:

• Single-agent NSAIDs like ibuprofen (400-800 mg every six hours) 1
• Naproxen sodium (275-550 mg every two to six hours) 1
• Acetaminophen alone (650-1000 mg every four to six hours) 1

Midol represents a specific combination product that targets multiple symptoms associated with menstrual discomfort through its three active ingredients working through different mechanisms of action.