Differential Diagnosis
- Single most likely diagnosis
- Systemic Lupus Erythematosus (SLE): This is the most likely diagnosis due to the "full house" immune complex deposition pattern, which is characteristic of SLE. The presence of immune complexes in both mesangial areas and along glomerular capillary basement membranes, as well as extraglomerular deposits, is highly suggestive of this autoimmune disease.
- Other Likely diagnoses
- IgA Nephropathy: Although the "full house" pattern is more typical of SLE, IgA nephropathy can also present with mesangial immune complex deposition. However, the presence of extraglomerular deposits and the specific pattern of immune complex deposition might make SLE more likely.
- Mixed Connective Tissue Disease: This disease can present with a combination of features from different autoimmune diseases, including SLE, and might show similar immune complex deposition patterns.
- Do Not Miss
- Goodpasture Syndrome: Although less likely given the "full house" pattern, Goodpasture syndrome is a critical diagnosis not to miss due to its potential for rapid progression to severe kidney disease and the availability of specific treatment. It typically presents with linear IgG deposition along glomerular basement membranes rather than the described pattern.
- ANCA-associated Vasculitis: This condition can present with renal involvement and immune complex deposition, although the pattern might differ. It's crucial to consider due to its potential for severe organ damage and the importance of early treatment.
- Rare diagnoses
- Membranoproliferative Glomerulonephritis (MPGN): While MPGN can present with immune complex deposition, the described "full house" pattern and extraglomerular deposits are less typical for this condition. MPGN is characterized by a different pattern of glomerular injury.
- C3 Glomerulopathy: This includes diseases like dense deposit disease and C3 glomerulonephritis, which are characterized by the deposition of complement factors in the glomeruli. The clinical presentation and immune complex deposition pattern might not fully align with the provided description, making it a less likely but rare consideration.