From the Guidelines
Prednisone liquid solution is an oral corticosteroid medication available for patients who have difficulty swallowing tablets, with a standard concentration typically of 5 mg/5 mL or 5 mg/1 mL. The medication is used to suppress inflammation and immune responses through inhibition of inflammatory mediators. For adults, typical dosing ranges from 5-60 mg daily, while pediatric dosing is weight-based, usually 0.5-2 mg/kg/day divided into 1-4 doses, as seen in guidelines for various conditions, such as glomerulonephritis where a daily single dose of 1 mg/kg (maximum 80 mg) or an alternate-day dose of 2 mg/kg (a maximum dose of 120 mg) is suggested 1. Some key points to consider when administering prednisone liquid solution include:
- Measuring the solution using the provided dosing cup, oral syringe, or measuring spoon for accuracy
- Mixing with a small amount of juice or applesauce just before administration to mask the bitter taste
- Taking the medication with food to reduce stomach irritation
- Following a tapering schedule when discontinuing after prolonged use to prevent adrenal insufficiency Common side effects of prednisone include increased appetite, mood changes, insomnia, and with long-term use, potential for weight gain, elevated blood sugar, and bone density loss.
From the FDA Drug Label
DESCRIPTION PredniSONE Tablets contain prednisone which is a glucocorticoid. It is very slightly soluble in water; slightly soluble in alcohol, chloroform, dioxane, and methanol
The FDA drug label does not answer the question about prednisone liquid solution, as it only describes PredniSONE Tablets and their composition, with no information about a liquid solution formulation 2.
From the Research
Definition and Forms of Prednisone
- Prednisone is a corticosteroid that can be administered in various forms, including oral tablets and liquid solutions 3, 4, 5, 6, 7.
- The liquid solution of prednisone is often used for patients who have difficulty swallowing tablets or require a more precise dose.
Uses of Prednisone Liquid Solution
- Prednisone liquid solution is used to treat various conditions, such as rheumatoid arthritis, asthma, and other inflammatory diseases 3, 4, 5, 6, 7.
- It is often prescribed in low doses to control inflammatory features and prevent bony damage in patients with rheumatoid arthritis 3, 7.
- In asthma patients, prednisone liquid solution can be used to reduce inflammation and prevent exacerbations 4, 5, 6.
Administration and Dosage
- The dosage of prednisone liquid solution varies depending on the condition being treated and the patient's response to the medication 3, 4, 5, 6, 7.
- It is essential to follow the prescribed dosage and administration schedule to minimize side effects and ensure the effectiveness of the treatment 3, 4, 5, 6, 7.
Comparison with Other Forms of Corticosteroids
- Studies have compared the efficacy and safety of prednisone with other corticosteroids, such as methylprednisolone and hydrocortisone 4, 5, 6.
- The results suggest that prednisone can be an effective and safe treatment option for various conditions, with minimal side effects when used in low doses 3, 7.