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Last updated: September 15, 2025View editorial policy

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Differential Diagnosis for Occult Blood in Stools in Infants

Single Most Likely Diagnosis

  • Allergic colitis: This condition is a common cause of occult blood in stools in infants, often associated with cow's milk protein allergy. It leads to inflammation and microscopic bleeding in the colon.

Other Likely Diagnoses

  • Anal fissure: A tear in the anal mucosa can cause pain and bleeding during bowel movements, leading to occult blood in stools.
  • Gastroesophageal reflux disease (GERD): Although more commonly associated with vomiting and irritability, GERD can also lead to occult blood in stools due to esophageal or gastric mucosal injury.
  • Infectious colitis: Bacterial or viral infections can cause inflammation and bleeding in the colon, resulting in occult blood in stools.

Do Not Miss Diagnoses

  • Intussusception: A condition where a part of the intestine telescopes into another, leading to bowel obstruction and potentially life-threatening complications if not promptly diagnosed and treated.
  • Meckel's diverticulum: A congenital anomaly of the small intestine that can cause bleeding due to the presence of ectopic gastric mucosa.
  • Hirschsprung's disease: A congenital condition characterized by the absence of ganglion cells in the distal bowel, leading to obstruction and potentially enterocolitis, which can cause occult blood in stools.

Rare Diagnoses

  • Juvenile polyps: Benign growths in the colon that can cause bleeding, although rare in infants.
  • Inflammatory bowel disease (IBD): Conditions like Crohn's disease and ulcerative colitis are rare in infants but can cause occult blood in stools due to chronic inflammation of the gastrointestinal tract.
  • Vascular malformations: Abnormalities in blood vessels, such as hemangiomas, can cause bleeding in the gastrointestinal tract, although this is a rare cause of occult blood in stools in infants.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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