Recommended Dosing for Cambia (Diclofenac Potassium) in Migraine Treatment

The recommended dose of Cambia (diclofenac potassium) for acute migraine treatment is 50 mg as a single oral solution dose. 1, 2, 3

Cambia (Diclofenac Potassium) Administration

Cambia is a fast-acting oral solution formulation of diclofenac potassium specifically designed for rapid absorption in acute migraine treatment
The standard dose is 50 mg mixed in water as a single oral dose at migraine onset 2, 3
Clinical evidence shows that the 50 mg dose provides effective relief with no additional benefit from higher doses 2
The oral solution formulation (Cambia) offers faster absorption compared to traditional diclofenac tablets 3

Diclofenac potassium provides significant pain relief starting from 60 minutes after administration 4, 5
The medication continues to provide relief throughout the 8-hour observation period 4
Cambia has demonstrated similar efficacy to intramuscular ketorolac in treating severe migraines, making it a viable alternative to parenteral treatment 3
The Numbers Needed to Treat (NNT) for diclofenac potassium 50 mg versus placebo are:
- 6.2 for pain-free at two hours
- 8.9 for headache relief at two hours
- 9.5 for pain-free responses at 24 hours 2

NSAIDs, including diclofenac, are recommended as first-line therapy for most migraine sufferers 6
For patients with moderate to severe attacks or those who don't respond to initial NSAID therapy, migraine-specific agents (triptans, DHE) should be considered 6, 1
Cambia may be particularly useful for patients with significant nausea as it is available as an oral solution and has shown favorable effects on reducing nausea compared to some other treatments 5

Diclofenac potassium is generally well-tolerated with adverse events mostly mild and transient 2
Studies show that adverse events occur at approximately the same rate as with placebo 2
The most commonly reported side effects include abdominal pain, tiredness, fatigue, and nausea, which are typically mild to moderate 5
Cambia has shown a more favorable tolerability profile compared to oral sumatriptan in comparative studies 4, 5

To avoid medication overuse headache, limit acute therapy to no more than twice per week 1
NSAIDs should be limited to no more than 15 days per month to prevent medication overuse headache 1
Consider preventive therapy if migraine attacks occur two or more times per month with disability lasting 3 or more days per month 6
Patients with cardiovascular risk factors should use NSAIDs with caution due to potential cardiovascular risks with prolonged use

Faster onset of action compared to conventional diclofenac tablets and oral sumatriptan 5
More effective in reducing accompanying symptoms like nausea and vomiting compared to some other treatments 4, 5
The oral solution formulation may be beneficial for patients who have difficulty swallowing tablets during migraine attacks