What is the diagnosis for a 40-year-old male (m) presenting with a less than 24-hour history of a red and painful right eye?

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Differential Diagnosis for Acute Red and Painful Eye

  • Single most likely diagnosis
    • Acute conjunctivitis: This is the most common cause of a red and painful eye, often presenting with discharge, tearing, and irritation. The acute onset and symptoms are consistent with this diagnosis.
  • Other Likely diagnoses
    • Acute angle-closure glaucoma: Although less common, this condition can cause severe eye pain, redness, and vision changes, often accompanied by nausea and vomiting. The short duration of symptoms could fit this diagnosis.
    • Corneal ulcer: A corneal ulcer can cause significant pain, redness, and sensitivity to light, and can develop rapidly. Contact lens use or trauma could predispose to this condition.
    • Episcleritis: This is an inflammatory condition of the episclera, a thin layer on top of the white part of the eye, which can cause redness and pain, but typically less severe than scleritis.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Endophthalmitis: A severe, sight-threatening infection within the eye that requires prompt treatment. It is less common but critical to diagnose early due to its potential for severe vision loss.
    • Scleritis: A more severe inflammatory condition than episcleritis, scleritis can cause intense pain, redness, and sensitivity to light. It is less common but can lead to serious complications if not treated properly.
    • Orbital cellulitis: An infection of the tissues surrounding the eye, which can cause pain, redness, swelling, and vision changes. It is a medical emergency due to the risk of serious complications, including vision loss and cavernous sinus thrombosis.
  • Rare diagnoses
    • Uveitis: Inflammation of the uvea, the middle layer of the eye, which can cause pain, redness, and sensitivity to light. It is less common and can be associated with systemic diseases.
    • Keratitis: Inflammation of the cornea, which can be caused by infection or injury, leading to pain, redness, and vision changes. Certain types, like herpes simplex keratitis, can have a more subacute presentation but are important to consider in the differential diagnosis of a red and painful eye.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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