From the Guidelines
Evening primrose oil (EPO) and Tryptophan should be used with caution in patients with breast cancer in remission experiencing hot flushes, as there is no absolute contraindication but potential concerns exist. The primary concern with using EPO in breast cancer patients is its potential estrogenic effects, which may be problematic for hormone-sensitive breast cancer patients 1. However, the evidence on the safety and efficacy of EPO in breast cancer survivors is limited and mixed. Some studies suggest that non-hormonal treatments, such as venlafaxine, gabapentin, or clonidine, may be safer alternatives for managing hot flushes in breast cancer patients, as they do not have estrogenic effects 1. Lifestyle modifications, such as weight loss, exercise, and avoiding triggers like spicy foods and alcohol, may also help alleviate hot flushes in breast cancer survivors 1. Additionally, cognitive behavioral therapy (CBT) and other non-pharmacologic interventions may be beneficial in reducing vasomotor symptoms in breast cancer survivors 1. It is essential to consult with an oncologist before starting any supplement, especially with a history of breast cancer, to determine the best course of treatment and minimize potential risks. In general, the use of hormonal therapies, including EPO, should be individualized and based on the patient's specific cancer type, treatment history, and overall health status 1.
From the Research
Contraindications for Evening Primrose Oil (EPO) and Tryptophan in Breast Cancer Patients
- There is no direct evidence in the provided studies to suggest a contraindication for the use of Evening Primrose Oil (EPO) and Tryptophan in patients with hot flushes and breast cancer in remission 2, 3, 4, 5, 6.
- However, it is essential to consider the potential interactions and effects of these supplements on breast cancer patients, particularly those undergoing chemotherapy or taking anti-oestrogen medications.
- A study on the anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy found that this combination may help reduce cancer complications resulting from impaired lipid metabolism and inflammation 6.
- Another study suggested that stellate-ganglion block can provide relief from hot flushes and sleep dysfunction in breast cancer survivors, which may be an alternative or complementary approach to managing symptoms 5.
- The use of hormone replacement therapy (HRT) in breast cancer survivors is still a topic of debate, and the decision to use HRT should be made on a case-by-case basis, considering the potential benefits and risks 2, 3.
- Selective estrogen receptor modulators (SERMs) may be an option for managing hot flushes and preventing breast cancer recurrence, but their use should be carefully considered due to potential adverse effects 4.