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Differential Diagnosis for New Onset Squint in a 90-Year-Old

Single Most Likely Diagnosis

  • Age-related decompensation of pre-existing phoria: This is the most likely cause due to the weakening of extraocular muscles and the reduction in neural control with age, leading to the manifestation of a previously compensated strabismus.

Other Likely Diagnoses

  • Diabetic third nerve palsy: A common cause of new onset squint in older adults, resulting from microvascular ischemia affecting the third cranial nerve.
  • Thyroid eye disease: Although more common in younger populations, thyroid disorders can occur at any age and may cause strabismus due to extraocular muscle involvement.
  • Stroke or cerebral vasculature issues: Vascular events can lead to problems with eye movement and alignment, presenting as a squint.

Do Not Miss Diagnoses

  • Giant cell arteritis: A condition that, although rare, is critical to diagnose due to its potential to cause blindness if not treated promptly. It can present with diplopia among other symptoms.
  • Brain tumor or metastasis: Although less common, a new onset squint could be a presenting symptom of a space-occupying lesion affecting the brainstem or cranial nerves.
  • Myasthenia gravis: An autoimmune disorder that can cause fluctuating weakness of the extraocular muscles, leading to intermittent squint.

Rare Diagnoses

  • Graves' disease with restrictive myopathy: While thyroid eye disease is more common, the specific presentation with restrictive myopathy causing squint is less frequent.
  • Ocular myasthenia gravis: A localized form of myasthenia gravis affecting only the eyes, which can cause diplopia and squint.
  • Intracranial aneurysm: Although rare, an aneurysm pressing on a cranial nerve can cause a squint, making it a diagnosis that should not be overlooked despite its low probability.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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