Differential Diagnosis for New Onset Squint in a 90-Year-Old
Single Most Likely Diagnosis
- Age-related decompensation of pre-existing phoria: This is the most likely cause due to the weakening of extraocular muscles and the reduction in neural control with age, leading to the manifestation of a previously compensated strabismus.
Other Likely Diagnoses
- Diabetic third nerve palsy: A common cause of new onset squint in older adults, resulting from microvascular ischemia affecting the third cranial nerve.
- Thyroid eye disease: Although more common in younger populations, thyroid disorders can occur at any age and may cause strabismus due to extraocular muscle involvement.
- Stroke or cerebral vasculature issues: Vascular events can lead to problems with eye movement and alignment, presenting as a squint.
Do Not Miss Diagnoses
- Giant cell arteritis: A condition that, although rare, is critical to diagnose due to its potential to cause blindness if not treated promptly. It can present with diplopia among other symptoms.
- Brain tumor or metastasis: Although less common, a new onset squint could be a presenting symptom of a space-occupying lesion affecting the brainstem or cranial nerves.
- Myasthenia gravis: An autoimmune disorder that can cause fluctuating weakness of the extraocular muscles, leading to intermittent squint.
Rare Diagnoses
- Graves' disease with restrictive myopathy: While thyroid eye disease is more common, the specific presentation with restrictive myopathy causing squint is less frequent.
- Ocular myasthenia gravis: A localized form of myasthenia gravis affecting only the eyes, which can cause diplopia and squint.
- Intracranial aneurysm: Although rare, an aneurysm pressing on a cranial nerve can cause a squint, making it a diagnosis that should not be overlooked despite its low probability.