From the FDA Drug Label
Patients with known aspirin sensitivity should be advised to continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking SINGULAIR. The patient can take Montelukast (Singulair) while using Aspirin (Acetylsalicylic Acid), but caution is advised for patients with known aspirin sensitivity. They should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking SINGULAIR 1.
From the Research
It is generally safe for a patient to take montelukast (Singulair) while using aspirin, as there are no significant drug interactions between them that would prevent concurrent use. These medications can be used together, and their different mechanisms of action allow them to work independently in the body. Montelukast works by blocking leukotriene receptors to reduce inflammation in airways, while aspirin inhibits prostaglandin production through COX enzyme inhibition 2. However, patients with aspirin sensitivity or aspirin-exacerbated respiratory disease (AERD) should be cautious, as they may experience respiratory symptoms with aspirin use regardless of montelukast therapy.
Some key points to consider when taking montelukast and aspirin together include:
- Aspirin use can increase the risk of gastrointestinal bleeding, especially in older adults or those with a history of bleeding disorders 3
- The use of proton-pump inhibitors (PPIs) can decrease the risk of gastrointestinal bleeding in patients taking aspirin 4
- The risk of upper gastrointestinal bleeding associated with low-dose aspirin is higher in primary prevention patients than in secondary prevention patients, but the baseline risk is lower in primary prevention patients 5
- Patients should always inform their doctor about all medications they are taking to ensure there are no individual contraindications based on their specific health conditions.
In terms of morbidity, mortality, and quality of life, the benefits of taking montelukast and aspirin together should be weighed against the potential risks. According to a recent study, the use of low-dose aspirin in primary prevention patients may not be beneficial for everyone, and the risk of bleeding should be carefully considered 6. However, for patients who require aspirin therapy, the use of montelukast is not likely to increase the risk of adverse effects. Overall, the decision to take montelukast and aspirin together should be made on a case-by-case basis, taking into account the individual patient's medical history and health status.