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Last updated: September 16, 2025View editorial policy

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Differential Diagnosis for Thumb Pain

  • Single most likely diagnosis
    • Osteoarthritis: This is a common condition, especially in older adults, where the cartilage that cushions the joints wears away, leading to pain and stiffness. The thumb is a frequently affected area due to its heavy use and complex joint structure.
  • Other Likely diagnoses
    • Trigger thumb (Stenosing tenosynovitis): This condition involves inflammation of the tendon sheath, causing pain, stiffness, and a clicking or snapping sensation when moving the thumb.
    • De Quervain's tenosynovitis: Inflammation of the tendons on the thumb side of the wrist, leading to pain and tenderness, especially when forming a fist, grasping, or turning the wrist.
    • Thumb sprain: An injury to the ligaments surrounding the thumb joints, often resulting from sudden twisting or bending.
  • Do Not Miss diagnoses
    • Scaphoid fracture: A break in one of the small bones of the wrist, which can be difficult to diagnose and may lead to serious complications if not properly treated.
    • Infectious tenosynovitis: A bacterial infection of the tendon sheath, which can lead to severe consequences, including tendon rupture or spread of infection, if not promptly addressed.
    • Giant cell tumor of the tendon sheath: A rare, benign tumor that can cause pain, swelling, and decreased mobility if not diagnosed and treated.
  • Rare diagnoses
    • Thumb gout: A form of arthritis caused by the buildup of uric acid crystals in the joints, which can lead to sudden, severe attacks of pain and swelling.
    • Psoriatic arthritis: A type of arthritis that occurs in some people with psoriasis, causing joint pain, stiffness, and swelling, including in the thumb.
    • Sarcoidosis: A condition in which inflammatory cells form lumps known as granulomas in various parts of the body, including the joints, which can cause pain and stiffness in the thumb.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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