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Differential Diagnosis for Low Globulin in Blood with Bowel Habit Change

  • Single Most Likely Diagnosis
    • Malabsorption due to celiac disease: This is a common cause of low globulin levels, as celiac disease can lead to malabsorption of proteins and other nutrients. The bowel habit change could be related to the malabsorption, making this a likely diagnosis.
  • Other Likely Diagnoses
    • Inflammatory bowel disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause malabsorption and changes in bowel habits, leading to low globulin levels.
    • Giardiasis: This parasitic infection can cause malabsorption and changes in bowel habits, potentially leading to low globulin levels.
    • Lymphoma: Certain types of lymphoma, such as intestinal lymphoma, can cause malabsorption and changes in bowel habits, leading to low globulin levels.
  • Do Not Miss Diagnoses
    • Whipple's disease: This rare bacterial infection can cause malabsorption, changes in bowel habits, and low globulin levels. If missed, it can lead to severe complications and death.
    • Amyloidosis: This condition can cause low globulin levels and changes in bowel habits, and if missed, can lead to severe organ damage and death.
  • Rare Diagnoses
    • Abetalipoproteinemia: This rare genetic disorder can cause malabsorption of fats and fat-soluble vitamins, leading to low globulin levels and changes in bowel habits.
    • Immunoglobulin deficiency: Certain immunoglobulin deficiencies, such as selective IgA deficiency, can cause low globulin levels and changes in bowel habits.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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