How many clicks are needed for a 0.25 mg dose of Ozempic (semaglutide) and do I need to prime the pen?

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Last updated: September 17, 2025View editorial policy

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Ozempic Pen Dosing Instructions for 0.25 mg Dose

For a 0.25 mg dose of Ozempic using the 0.25 mg/pen, you need to dial to 1 click (which equals 0.25 mg) and yes, you must prime the pen before the first use.

Pen Preparation and Priming Instructions

First-Time Pen Preparation:

  1. Check the pen: Ensure you have the correct Ozempic pen (0.25 mg/pen)
  2. Prime the pen before first use:
    • Remove the pen cap
    • Check that the solution is clear and colorless
    • Attach a new needle
    • Hold the pen with the needle pointing upward
    • Turn the dose selector until the dose counter shows the priming symbol (flow check symbol)
    • Press and hold the dose button until the dose counter returns to 0 and a drop appears at the needle tip

For Your 0.25 mg Dose:

  • After priming, turn the dose selector to select 1 click (which equals 0.25 mg)
  • Insert the needle as directed by your healthcare provider
  • Press and hold the dose button until the dose counter shows 0
  • Keep the button pressed and count slowly to 6 before removing the needle

Important Notes:

  • Priming is only needed before the first injection with each new pen
  • For subsequent doses with the same pen, priming is not required
  • The 0.25 mg/pen is specifically designed so that 1 click equals 0.25 mg
  • Store unused pens in the refrigerator (36°F to 46°F)
  • After first use, the pen can be stored at room temperature (below 86°F) for up to 56 days

Potential Side Effects to Monitor:

  • Gastrointestinal effects are common when starting Ozempic (nausea, vomiting, diarrhea)
  • These side effects are typically mild to moderate and decrease over time
  • Stay well hydrated, especially if you experience gastrointestinal side effects

Remember to dispose of used needles properly in a sharps container and never reuse needles.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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