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Differential Diagnosis for Penile Pain in an Uncircumcised Male

Single Most Likely Diagnosis

  • Phimosis: This condition, where the foreskin cannot be fully retracted over the glans penis, is common in uncircumcised males and can cause pain, especially during erection or sexual activity. The tight foreskin can lead to discomfort, pain, and sometimes urinary difficulties.

Other Likely Diagnoses

  • Balanitis: An inflammation of the glans penis, often associated with poor hygiene, which can be painful and is more common in uncircumcised males due to the warm, moist environment under the foreskin.
  • Posthitis: Inflammation of the foreskin, which can cause pain, swelling, and redness. It often occurs in conjunction with balanitis (balanoposthitis).
  • Urinary Tract Infection (UTI): While not exclusive to uncircumcised males, UTIs can cause penile pain, especially during urination, and are a common issue that needs to be considered.
  • Sexually Transmitted Infections (STIs): Various STIs, such as gonorrhea, chlamydia, and herpes, can cause penile pain, discharge, and other symptoms.

Do Not Miss Diagnoses

  • Penile Fracture: A serious condition that occurs when the penis is injured, often during sexual activity, leading to a painful and potentially debilitating condition requiring immediate medical attention.
  • Penile Cancer: Although rare, penile cancer can present with pain and should not be missed, as early detection significantly improves prognosis.
  • Epididymitis: Inflammation of the epididymis (the tube at the back of the testicle that stores and carries sperm), which can cause severe pain and is a medical emergency if not promptly treated.

Rare Diagnoses

  • Peyronie's Disease: A condition characterized by the development of scar tissue inside the penis, leading to curved, painful erections.
  • Penile Vasculitis: Inflammation of the blood vessels in the penis, which can cause pain and is associated with various systemic diseases.
  • Neurogenic Pain: Pain originating from nerve damage or dysfunction, which can be challenging to diagnose and treat.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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