How do you administer Volteren (Diclofenac) gel?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

How to Administer Voltaren (Diclofenac) Gel

Diclofenac gel should be applied to clean, dry skin 3 times daily to the affected area, spreading it evenly without massaging it into the skin. 1

Proper Application Technique

Preparation

  • Wash hands thoroughly with soap and water before application
  • Ensure the area to be treated is clean and dry
  • Wait until the area is completely dry if you've recently bathed or showered (at least 30 minutes) 2

Application Steps

  1. Remove the cap from the tube
  2. Apply a small amount of gel (approximately the size of a cherry to a quarter, depending on the size of the area) directly to the affected area
  3. Spread the gel evenly around the front, back, and sides of the affected area without rubbing or massaging it in 2
  4. Wash hands immediately and thoroughly after application to avoid accidental contact with eyes, mouth, or other mucous membranes 2

Post-Application Precautions

  • Allow the treated area to dry completely (approximately 10-15 minutes) before:
    • Covering with clothing
    • Applying sunscreen, insect repellent, cosmetics, or other topical medications 2
  • Avoid skin-to-skin contact between other people and the treated area until completely dry 2
  • Do not apply external heat or occlusive dressings to the treated area 2
  • Avoid showering or bathing for at least 30 minutes after application 2

Dosing Frequency and Duration

  • Apply diclofenac gel 3 times daily to the affected area 1
  • Use the lowest effective dosage for the shortest duration consistent with treatment goals 2
  • For actinic keratosis treatment, application is typically twice daily for 60-90 days 1

Special Considerations

Efficacy and Absorption

  • Diclofenac gel penetrates into underlying tissues, with steady-state levels in muscle tissue near the application site approximately 3 times higher than in distant muscle tissue 3
  • The gel formulation provides both hydrating and cooling effects, with skin temperature reduction of approximately 5.8°C within 10 minutes of application 4

Warnings and Precautions

  • Avoid contact with eyes, nose, or mouth 2
  • Do not apply to open wounds or broken skin 2
  • Protect treated areas from natural and artificial sunlight 2
  • Do not use combination therapy with diclofenac gel and oral NSAIDs unless the benefit outweighs the risk 2

Common Side Effects

  • Local skin reactions such as pruritus (itching) and rash are the most common side effects 1
  • Diclofenac gel typically causes less intense local skin reactions than other topical treatments like 5-FU or imiquimod 5% cream 1

By following these application instructions carefully, you can maximize the effectiveness of Voltaren (diclofenac) gel while minimizing potential side effects or complications.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[The percutaneous absorption of diclofenac].

Arzneimittel-Forschung, 1986

Research

Skin hydration and cooling effect produced by the Voltaren® vehicle gel.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.