From the Guidelines
Adrenal gland issues can manifest with a range of symptoms, including those related to cortisol and aldosterone deficiency, such as fatigue, weight loss, and hypotension, as well as symptoms of excess cortisol, like weight gain, hypertension, and hyperglycemia. The adrenal glands produce essential hormones, including cortisol, aldosterone, and sex hormones, which play a crucial role in regulating various bodily functions, including metabolism, immune response, and blood pressure control 1. Disorders of the adrenal glands, such as Addison's disease, Cushing's syndrome, and adrenal insufficiency, can have significant impacts on morbidity, mortality, and quality of life.
Symptoms of Adrenal Gland Issues
Some common symptoms of adrenal gland issues include:
- Fatigue and weakness
- Weight loss or gain
- Hypotension or hypertension
- Hyperglycemia or hypoglycemia
- Electrolyte imbalances
- Skin changes, such as thinning or bruising
- Mood changes, such as anxiety or depression These symptoms can vary depending on the specific disorder and the individual affected, and may require referral to an endocrinologist for proper diagnosis and management 1.
Importance of Proper Adrenal Function
Proper adrenal function is crucial for maintaining homeostasis, managing stress, and regulating various bodily functions, including metabolism, immune response, and blood pressure control 1. Adrenal insufficiency, in particular, can be life-threatening if not properly managed, and patients with this condition require education on stress dosing, emergency injectables, and medical alert systems to prevent adrenal crisis.
Management of Adrenal Gland Issues
Management of adrenal gland issues typically involves replacement therapy with hormones such as hydrocortisone and fludrocortisone, as well as lifestyle modifications to manage stress and prevent complications 1. In some cases, surgery or other interventions may be necessary to treat underlying conditions, such as tumors or congenital adrenal hyperplasia. Early endocrinology consultation is essential for planning and managing patients with adrenal gland issues, particularly those undergoing surgery or high-stress treatments.
From the FDA Drug Label
Adrenal insufficiency is a condition in which the adrenal glands do not make enough steroid hormones. Ketoconazole tablets may cause adrenal insufficiency if you take a high dose. Call your healthcare provider right away if you have symptoms of adrenal insufficiency such as tiredness, weakness, dizziness, nausea, and vomiting.
The symptoms of adrenal gland (adrenal) issues that may be caused by ketoconazole tablets include:
From the Research
Symptoms of Adrenal Gland Issues
The symptoms of adrenal gland issues can vary depending on the specific condition. Some common symptoms include:
- Fatigue and weakness 3, 4
- Loss of appetite 5
- Nausea 5
- Muscle weakness 5, 4
- Facial edema 5
- Depression 4
- Emotional lability 4
- Hypokalemia-induced weakness 4
- Behavioral disturbances 4
Adrenal Insufficiency Symptoms
Adrenal insufficiency, in particular, can cause non-specific symptoms, including:
Other Adrenal Gland Disorders
Other adrenal gland disorders, such as Cushing's syndrome, primary aldosteronism, and adrenoleukodystrophy, can also cause a range of symptoms, including: