Allergic reaction to Metoprolol: Metoprolol, a beta-blocker, is known to cause allergic reactions, including skin manifestations like hives and pruritus, although it is less common compared to other medications. The timing of the rash after starting Metoprolol supports this possibility.

Allergic reaction to Aliquis (Apixaban): While less common, direct oral anticoagulants like Apixaban can cause skin reactions, including pruritic rashes and hives. The onset of symptoms after initiation of Aliquis makes it a plausible cause.
Drug-induced urticaria: Both Metoprolol and Aliquis can potentially cause urticaria, a condition characterized by the appearance of hives, which is often accompanied by pruritus. This is a common adverse effect of many medications.

Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN): Although rare, these severe skin conditions can be life-threatening and are associated with medication use, including beta-blockers and anticoagulants. Early recognition is crucial for management and preventing severe outcomes.
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS): This is a severe drug reaction that can occur with various medications, including those used for cardiovascular diseases. It is characterized by rash, fever, lymphadenopathy, and eosinophilia, and can be life-threatening if not recognized and treated promptly.

Fixed drug eruption: A type of drug reaction that recurs at the same site each time the offending drug is taken. It's less likely but should be considered if the rash is localized and recurs upon re-exposure to the medication.
Serum sickness-like reaction: Some medications can cause a serum sickness-like reaction, which includes symptoms like rash, fever, and arthralgias. This is rare and would be considered if other common causes are ruled out.