What are the post-discharge instructions and medication recommendations for a post-operative patient going home?

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Last updated: September 18, 2025View editorial policy

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Post-Discharge Instructions and Medication Recommendations for Post-Operative Patients

For post-operative patients being discharged home, provide clear instructions on medication management, wound care, activity restrictions, and follow-up care, with opioids limited to no more than 7 days and a focus on multimodal non-opioid pain management. 1

Pain Management

Medication Protocol

  • First-line pain management:
    • Acetaminophen 650 mg PO every 6 hours scheduled
    • Ibuprofen 600 mg PO every 6 hours scheduled 1, 2
  • For breakthrough pain only:
    • Short-acting opioids (if needed)
    • Prescribe no more than 5-7 days of opioids 1
    • Dosage should be individualized based on inpatient opioid requirements

Opioid Management

  • Prescribe opioids separately from non-opioid analgesics to allow for dose adjustments 1
  • Patients should keep a record of all analgesics taken 1
  • Avoid modified-release opioid preparations (including transdermal patches) 1
  • Instruct patients to:
    • Store opioids securely away from others
    • Never drive or operate machinery while taking opioids
    • Dispose of unused opioids at a community pharmacy 1

Weaning Protocol

  • Follow reverse analgesic ladder: wean opioids first, then NSAIDs, then acetaminophen 1

Nausea and Vomiting Management

For Persistent Nausea/Vomiting

  • First-line: 5-HT3 antagonist (e.g., ondansetron) 1
  • Add if needed:
    • Anticholinergic agent (e.g., scopolamine) or
    • Antihistamine (e.g., meclizine) 1
  • For severe cases: Consider adding dexamethasone 1, 2

Constipation Prevention

Protocol

  • Increase fluid intake
  • Increase dietary fiber if adequate fluid intake
  • Exercise as appropriate 1
  • For opioid-induced constipation:
    • Senna ± docusate, 2-3 tablets BID with goal of one non-forced bowel movement every 1-2 days 1
    • If constipation persists: Add bisacodyl 10-15 mg daily-TID 1

Diarrhea Management

If Diarrhea Occurs

  • Ensure oral hydration and electrolyte replacement
  • Consider loperamide 4 mg PO x 1, then 2 mg after each loose stool (max 16 mg/day) 1
  • Recommend bland/BRAT diet (Bananas, Rice, Applesauce, Toast) 1

Wound Care

General Instructions

  • Keep the wound clean and dry
  • Cover with clean, dry dressing if drainage present or if in an area prone to friction 3
  • Avoid swimming until wound is completely healed (typically 1-2 weeks) 3
  • Avoid heavy lifting or strenuous exercise that might strain the wound site for 1-2 weeks 3

Special Considerations

  • For diabetic patients: More frequent wound checks and stricter wound care 3
  • For facial wounds: Additional sun protection for 6-12 months to minimize scarring 3
  • For wounds near joints: Additional activity restrictions to prevent tension on the wound 3

Activity Instructions

  • Early mobilization is encouraged, starting within hours after surgery 1
  • Gradually increase activity levels as tolerated
  • Resume normal activities according to surgeon's specific instructions
  • Return to work timing should be discussed based on type of surgery and job requirements

Follow-up Care

  • Schedule follow-up appointment as recommended by surgeon
  • Contact healthcare provider immediately if experiencing:
    • Fever >101°F
    • Increasing pain not controlled by prescribed medications
    • Excessive bleeding or wound drainage
    • Redness, warmth, or swelling at the incision site
    • Inability to tolerate fluids for 24 hours

Documentation Requirements

  • Discharge letter must explicitly state:
    • Recommended opioid dose and duration
    • Amount supplied
    • Planned duration of use 1
    • Clear instructions for medication weaning

Pitfalls to Avoid

  • Avoid adding postoperative opioids to "repeat" prescribing templates; they should only be prescribed as acute medications 1
  • Avoid prolonged opioid use - if patient is still taking opioids 90 days post-surgery, this should trigger further assessment for chronic post-surgical pain 1
  • Avoid prescribing antibiotics routinely at discharge unless specifically indicated 4, 5
  • Avoid requiring patients to urinate or drink clear fluids without vomiting before discharge, as this does not improve outcomes and extends recovery stay 1

By following these evidence-based discharge instructions, patients will experience improved pain control, reduced opioid consumption, and better overall recovery outcomes while minimizing complications.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Evidence-based cesarean delivery: postoperative care (part 10).

American journal of obstetrics & gynecology MFM, 2025

Guideline

Post-Suture Removal Care

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge Home Framework.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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