Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 18, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Generalized Itching and Hair Fall

Single Most Likely Diagnosis

  • Hypothyroidism: This condition is a common cause of generalized itching and hair fall. The thyroid hormone plays a crucial role in skin and hair health, and its deficiency can lead to these symptoms.

Other Likely Diagnoses

  • Atopic Dermatitis (Eczema): A chronic skin condition characterized by itchy, inflamed skin. Hair fall can occur due to excessive scratching or as a result of the underlying inflammatory process.
  • Psoriasis: An autoimmune condition that can cause itching and hair fall, especially if the scalp is involved.
  • Iron Deficiency Anemia: Iron deficiency can lead to hair fall and itching, possibly due to the role of iron in maintaining healthy skin and hair.
  • Vitamin Deficiencies (B12, D): Deficiencies in vitamins B12 and D have been associated with hair fall and itching, among other symptoms.

Do Not Miss Diagnoses

  • Hodgkin Lymphoma: Although rare, Hodgkin lymphoma can present with generalized itching (pruritus) as an early symptom, making it a critical diagnosis not to miss.
  • Chronic Kidney Disease: Itching can be a symptom of chronic kidney disease due to the buildup of toxins in the blood. Hair fall might also occur due to the systemic effects of the disease.
  • Hepatitis: Certain types of hepatitis can cause itching due to the accumulation of bile salts in the skin. Hair fall could be a secondary symptom due to the overall health impact of the disease.

Rare Diagnoses

  • Thyroid Storm: A life-threatening complication of untreated or undertreated hyperthyroidism, which can cause itching and hair fall among many other severe symptoms.
  • Polycythemia Vera: A rare blood disorder that can lead to itching (often after warm baths) and potentially hair fall due to the increased red blood cell mass and associated systemic effects.
  • Paraneoplastic Syndromes: Rare conditions associated with underlying cancers, which can cause a variety of symptoms including itching and hair fall.

Related Questions

How are chemotherapy drugs classified in the treatment of lung carcinoma?
What are the considerations for using Eliquis (apixaban) in patients with cirrhosis?
How do you manage elevated creatine kinase (CK) levels in patients with COVID-19 infection?
What is the management approach for cancer of the floor of the mouth?
What is the next step in management for a patient with irregular periods for 3 months, last menstrual period (LMP) on July 18th, and no change in the amount of bleeding?
What is the proper technique for administering a saline enema to children?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.

Ask Question