Calculating Water Volume for Anti-Flu Powder Reconstitution
To achieve a concentration of 12 mg/ml from 31g of anti-flu powder, you need to add 2,583 ml (approximately 2.58 liters) of water.
Calculation Method
The calculation to determine the correct volume of water follows a straightforward concentration formula:
First, convert the powder weight to milligrams:
- 31g = 31,000 mg
Apply the concentration formula:
- Concentration = Amount of drug / Volume
- 12 mg/ml = 31,000 mg / x ml
- x = 31,000 mg ÷ 12 mg/ml
- x = 2,583.33 ml
Verification
This calculation ensures that when 31g (31,000 mg) of the anti-flu powder is dissolved in 2,583 ml of water, the resulting solution will have the required concentration of 12 mg/ml.
Important Considerations
Measuring accuracy: Use a calibrated measuring device for precise water measurement.
Mixing technique: Ensure complete dissolution of the powder by:
- Adding the powder to a portion of the required water
- Stirring thoroughly until completely dissolved
- Adding the remaining water to reach the final volume
- Mixing again to ensure uniform concentration
Storage: Once reconstituted, follow the medication's specific storage instructions regarding:
- Temperature requirements
- Protection from light
- Expiration timeline after reconstitution
Clinical Context
While the guidelines reviewed primarily discuss standard dosing for influenza medications 1, the principles of pharmaceutical preparation apply to all medications. Proper reconstitution ensures accurate dosing, which is critical for achieving therapeutic efficacy while minimizing the risk of adverse effects.