What is the appropriate dressing for a split-thickness skin graft (STSG) to protect the graft?

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Last updated: February 10, 2025View editorial policy

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From the Guidelines

The most appropriate dressing for a split-thickness skin graft (STSG) to protect the graft is a non-adherent dressing, such as a silicone-based dressing, to prevent damage to the newly formed granulation tissue and promote graft take.

Key Considerations

  • The goal of dressing a STSG is to promote a moist environment that fosters wound healing and graft take, while minimizing the risk of infection and damage to the graft 1.
  • A non-adherent wound contact layer, such as a silicone-based dressing, should be used to prevent the growth of newly formed granulation tissue into the dressing, which can cause damage to the underlying tissue during dressing changes 1.
  • Occlusive dressings, such as film or hydrogel dressings, can also be used to promote wound healing by maintaining a moist environment and protecting the graft from external trauma 1.
  • There is no evidence to support the use of antibiotic or antibacterial dressings in clean wounds, as they do not improve wound healing or decrease infection rates 1.

Dressing Selection

  • The choice of dressing should be guided by the specific needs of the patient and the wound, including the size and location of the graft, as well as the presence of any underlying medical conditions 1.
  • Meshed split-skin grafts are a common technique used in wound closure, but the choice of dressing should be based on the individual patient's needs, rather than the specific grafting technique used 1.

From the Research

Dressing Options for Split-Thickness Skin Grafts

The choice of dressing for split-thickness skin grafts (STSG) is crucial for successful healing. Various types of dressings are available, including:

  • Hydrogel dressings 2
  • Alginate dressings 2, 3
  • Hydrocolloid dressings 3
  • Hydrofiber dressings 3
  • Silicone foam dressings 3
  • Polyurethane film dressings 3, 4, 5
  • Petrolatum gauze (Xeroform) 3

Characteristics of Ideal Dressings

The ideal dressing for STSG donor sites should:

  • Promote rapid reepithelialization 3, 4, 5
  • Minimize pain and discomfort 3, 4, 5
  • Reduce the risk of infection 3, 5
  • Be easy to use and apply 3, 4
  • Be cost-effective 3, 5

Comparison of Dressing Materials

Studies have compared the effectiveness of different dressing materials, including:

  • Hydrogel dressings vs. alginate dressings: hydrogel dressings may increase time to wound healing 2
  • Hydrogel dressings vs. hydrocolloid dressings: DuoDERM (hydrocolloid) elicited the greatest percent reepithelialization 3
  • Polyurethane film dressings vs. other dressings: polyurethane film dressings were associated with rapid reepithelialization and minimal pain 4, 5

Recommendations

Based on the available evidence, the following dressings may be suitable for STSG donor sites:

  • DuoDERM (hydrocolloid) for small donor sites when healing time is a priority 3
  • Xeroform (petrolatum gauze) for large donor-site areas due to its cost-effectiveness and ease of use 3
  • Polyurethane film dressings, such as Opsite, for their rapid reepithelialization and minimal pain 4, 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Hydrogel dressings for donor sites of split-thickness skin grafts.

The Cochrane database of systematic reviews, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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