Contact Dermatitis: This is a common condition that can cause clear blisters on the lower extremities due to an allergic reaction or irritation from substances like soap, detergent, or certain plants. The reaction typically occurs after exposure to the offending agent.

Eczema (Atopic Dermatitis): Characterized by itchy, inflamed skin, eczema can sometimes present with clear blisters, especially in acute phases or in specific types like dyshidrotic eczema.
Insect Bites: Bites from insects such as mosquitoes, fleas, or bed bugs can cause clear blisters due to the body's allergic reaction to the saliva injected by the insect during the bite.
Friction Blisters: Caused by repeated friction on the skin, these are common in areas like the feet, especially in new shoe wearers or athletes. While they are typically filled with fluid, the content can appear clear.

Cellulitis: Although it primarily presents with redness, swelling, and warmth, in some cases, especially if there's a break in the skin, cellulitis can lead to blister formation. It's a bacterial infection that requires prompt antibiotic treatment.
Necrotizing Fasciitis: A severe infection that can start with minor trauma, including blisters. It's characterized by rapid progression and can be life-threatening if not treated immediately.
Staphylococcal Scalded Skin Syndrome (SSSS): Caused by staphylococcal toxins, SSSS can present with blisters and is more common in children. It requires prompt recognition and treatment to prevent serious complications.

Bullous Pemphigoid: An autoimmune disease that causes blistering of the skin. It's more common in older adults and can be triggered by certain medications.
Epidermolysis Bullosa: A group of genetic conditions that result in fragile skin and blisters. These conditions are present from birth or early childhood.
Pemphigus Vulgaris: Another autoimmune disease that causes blisters, typically in the mouth and on the skin. It's rare and can be life-threatening if not treated properly.