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Differential Diagnosis for Hilar Lymphadenopathy in a Child

Single Most Likely Diagnosis

  • Sarcoidosis: Although more common in adults, sarcoidosis can occur in children and is known for causing hilar lymphadenopathy. It's an autoimmune disease that can affect multiple organs, including the lungs.

Other Likely Diagnoses

  • Tuberculosis (TB): TB is a common cause of hilar lymphadenopathy, especially in regions where TB is prevalent. It's a bacterial infection that primarily affects the lungs but can spread to other parts of the body.
  • Lymphoma: Both Hodgkin and non-Hodgkin lymphoma can present with hilar lymphadenopathy. Lymphomas are cancers of the immune system and can occur in children.
  • Infectious Mononucleosis: Caused by the Epstein-Barr virus, infectious mononucleosis can lead to lymphadenopathy, including in the hilar region, although it's more commonly associated with cervical lymphadenopathy.

Do Not Miss Diagnoses

  • Lymphangitic Carcinomatosis: Although rare in children, this condition involves the spread of cancer to the lymphatic vessels in the lungs and can cause hilar lymphadenopathy. It's crucial to consider in the differential due to its severe prognosis.
  • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A rare autoimmune disorder that can cause inflammation in the blood vessels, including those in the lungs, leading to hilar lymphadenopathy.
  • Histoplasmosis: A fungal infection that can cause lymphadenopathy, including in the hilar region, especially in endemic areas.

Rare Diagnoses

  • Castleman Disease: A rare disorder that involves an overgrowth of cells in the lymphatic system, which can lead to lymphadenopathy, including in the hilar region.
  • Kikuchi-Fujimoto Disease: A rare, self-limiting condition that causes lymphadenopathy, more commonly in the cervical region but can potentially involve the hilar lymph nodes.
  • Kimura Disease: A rare, chronic inflammatory disorder that can cause lymphadenopathy and eosinophilia, more commonly seen in Asian males.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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