What are the directions for taking Ubrelvy (Ubrogepant)?

Directions for Taking Ubrelvy (Ubrogepant)

The recommended dose of Ubrelvy is 50 mg or 100 mg taken orally with or without food. If needed, a second dose may be taken at least 2 hours after the initial dose. The maximum dose in a 24-hour period is 200 mg. 1

Dosing Instructions

• Take one tablet (50 mg or 100 mg) at the onset of migraine
• Can be taken with or without food
• If needed, a second dose can be taken at least 2 hours after the first dose
• Do not exceed 200 mg in a 24-hour period
• The safety of treating more than 8 migraines in a 30-day period has not been established 1

Dosage Modifications

For Drug Interactions:

• Moderate CYP3A4 Inhibitors: Initial dose 50 mg, avoid second dose within 24 hours
• Weak CYP3A4 Inhibitors: Initial dose 50 mg, second dose 50 mg if needed
• Strong CYP3A4 Inhibitors: Avoid concomitant use (contraindicated)
• Weak & Moderate CYP3A4 Inducers: Initial dose 100 mg, second dose 100 mg if needed
• BCRP and/or P-gp Inhibitors: Initial dose 50 mg, second dose 50 mg if needed 1

For Special Populations:

• Severe Hepatic Impairment (Child-Pugh Class C): Initial dose 50 mg, second dose 50 mg if needed
• Severe Renal Impairment (CLcr 15-29 mL/min): Initial dose 50 mg, second dose 50 mg if needed
• End-Stage Renal Disease (CLcr <15 mL/min): Avoid use 1

Important Considerations

• Ubrelvy is for acute treatment of migraine with or without aura in adults
• It is not indicated for preventive treatment of migraine 1
• Unlike triptans, Ubrelvy is a calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) 2
• Ubrelvy is effective in alleviating migraine-associated symptoms such as nausea, photophobia, and sound sensitivity 2

Potential Side Effects

• Most common adverse events include nausea, somnolence, and dry mouth 3
• Hypersensitivity reactions, including anaphylaxis, dyspnea, facial or throat edema, rash, urticaria, and pruritus have been reported
• If a serious or severe hypersensitivity reaction occurs, discontinue Ubrelvy and seek appropriate medical attention 1

Effectiveness Timeline

• In clinical trials, Ubrelvy demonstrated effectiveness in providing freedom from pain and most bothersome migraine symptoms at 2 hours after dosing 3
• Real-world studies show that approximately 75.8% of patients report satisfaction with migraine relief at 2 hours post-dose 4

Contraindications

• History of serious hypersensitivity to ubrogepant or any component of Ubrelvy
• Concomitant use with strong CYP3A4 inhibitors 1

By following these directions carefully, you can maximize the effectiveness of Ubrelvy for treating acute migraine attacks while minimizing potential side effects.